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G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.
Mathiasen S, Palmisano T, Perry NA, Stoveken HM, Vizurraga A, McEwen DP, Okashah N, Langenhan T, Inoue A, Lambert NA, Tall GG, Javitch JA. Mathiasen S, et al. Among authors: javitch ja. Nat Chem Biol. 2020 Dec;16(12):1343-1350. doi: 10.1038/s41589-020-0617-7. Epub 2020 Aug 10. Nat Chem Biol. 2020. PMID: 32778842 Free PMC article.
Rebuttal from Nevin A. Lambert and Jonathan A. Javitch.
Lambert NA, Javitch JA. Lambert NA, et al. Among authors: javitch ja. J Physiol. 2014 Jun 15;592(12):2449. doi: 10.1113/jphysiol.2014.274241. J Physiol. 2014. PMID: 24931947 Free PMC article. No abstract available.
A new mechanism of allostery in a G protein-coupled receptor dimer.
Lane JR, Donthamsetti P, Shonberg J, Draper-Joyce CJ, Dentry S, Michino M, Shi L, López L, Scammells PJ, Capuano B, Sexton PM, Javitch JA, Christopoulos A. Lane JR, et al. Among authors: javitch ja. Nat Chem Biol. 2014 Sep;10(9):745-52. doi: 10.1038/nchembio.1593. Epub 2014 Aug 10. Nat Chem Biol. 2014. PMID: 25108820 Free PMC article.
Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling.
Bellot M, Galandrin S, Boularan C, Matthies HJ, Despas F, Denis C, Javitch J, Mazères S, Sanni SJ, Pons V, Seguelas MH, Hansen JL, Pathak A, Galli A, Sénard JM, Galés C. Bellot M, et al. Nat Chem Biol. 2015 Apr;11(4):271-9. doi: 10.1038/nchembio.1766. Epub 2015 Feb 23. Nat Chem Biol. 2015. PMID: 25706338 Free PMC article.
282 results