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G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.
Mathiasen S, Palmisano T, Perry NA, Stoveken HM, Vizurraga A, McEwen DP, Okashah N, Langenhan T, Inoue A, Lambert NA, Tall GG, Javitch JA. Mathiasen S, et al. Among authors: langenhan t. Nat Chem Biol. 2020 Dec;16(12):1343-1350. doi: 10.1038/s41589-020-0617-7. Epub 2020 Aug 10. Nat Chem Biol. 2020. PMID: 32778842 Free PMC article.
Revisiting the classification of adhesion GPCRs.
Scholz N, Langenhan T, Schöneberg T. Scholz N, et al. Among authors: langenhan t. Ann N Y Acad Sci. 2019 Nov;1456(1):80-95. doi: 10.1111/nyas.14192. Epub 2019 Jul 31. Ann N Y Acad Sci. 2019. PMID: 31365134 Free PMC article.
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain.
Beliu G, Altrichter S, Guixà-González R, Hemberger M, Brauer I, Dahse AK, Scholz N, Wieduwild R, Kuhlemann A, Batebi H, Seufert F, Pérez-Hernández G, Hildebrand PW, Sauer M, Langenhan T. Beliu G, et al. Among authors: langenhan t. Mol Cell. 2021 Mar 4;81(5):905-921.e5. doi: 10.1016/j.molcel.2020.12.042. Epub 2021 Jan 25. Mol Cell. 2021. PMID: 33497605 Free article.
Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation.
Scholz N, Dahse AK, Kemkemer M, Bormann A, Auger GM, Vieira Contreras F, Ernst LF, Staake H, Körner MB, Buhlan M, Meyer-Mölck A, Chung YK, Blanco-Redondo B, Klose F, Jarboui MA, Ljaschenko D, Bigl M, Langenhan T. Scholz N, et al. Among authors: langenhan t. Nature. 2023 Mar;615(7954):945-953. doi: 10.1038/s41586-023-05802-5. Epub 2023 Mar 8. Nature. 2023. PMID: 36890234
51 results