O'Neill LAJ - Search Results

1

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation.

Hooftman A, Angiari S, Hester S, Corcoran SE, Runtsch MC, Ling C, Ruzek MC, Slivka PF, McGettrick AF, Banahan K, Hughes MM, Irvine AD, Fischer R, O'Neill LAJ. Hooftman A, et al. Cell Metab. 2020 Sep 1;32(3):468-478.e7. doi: 10.1016/j.cmet.2020.07.016. Epub 2020 Aug 12. Cell Metab. 2020. PMID: 32791101 Free PMC article.

2

The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction.

McGettrick AF, O'Neill LA. McGettrick AF, et al. Mol Immunol. 2004 Jul;41(6-7):577-82. doi: 10.1016/j.molimm.2004.04.006. Mol Immunol. 2004. PMID: 15219996 Review.

3

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.

Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT. Rowe DC, et al. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6299-304. doi: 10.1073/pnas.0510041103. Epub 2006 Apr 7. Proc Natl Acad Sci U S A. 2006. PMID: 16603631 Free PMC article.

4

Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.

McGettrick AF, Brint EK, Palsson-McDermott EM, Rowe DC, Golenbock DT, Gay NJ, Fitzgerald KA, O'Neill LA. McGettrick AF, et al. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9196-201. doi: 10.1073/pnas.0600462103. Epub 2006 Jun 6. Proc Natl Acad Sci U S A. 2006. PMID: 16757566 Free PMC article.

5

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

Miggin SM, Pålsson-McDermott E, Dunne A, Jefferies C, Pinteaux E, Banahan K, Murphy C, Moynagh P, Yamamoto M, Akira S, Rothwell N, Golenbock D, Fitzgerald KA, O'Neill LA. Miggin SM, et al. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3372-7. doi: 10.1073/pnas.0608100104. Epub 2007 Feb 20. Proc Natl Acad Sci U S A. 2007. PMID: 17360653 Free PMC article.

6

Toll-like receptors: key activators of leucocytes and regulator of haematopoiesis.

McGettrick AF, O'Neill LA. McGettrick AF, et al. Br J Haematol. 2007 Oct;139(2):185-93. doi: 10.1111/j.1365-2141.2007.06802.x. Br J Haematol. 2007. PMID: 17897294 Free article. Review.

7

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.

Palsson-McDermott EM, Doyle SL, McGettrick AF, Hardy M, Husebye H, Banahan K, Gong M, Golenbock D, Espevik T, O'Neill LA. Palsson-McDermott EM, et al. Nat Immunol. 2009 Jun;10(6):579-86. doi: 10.1038/ni.1727. Epub 2009 May 3. Nat Immunol. 2009. PMID: 19412184

8

Localisation and trafficking of Toll-like receptors: an important mode of regulation.

McGettrick AF, O'Neill LA. McGettrick AF, et al. Curr Opin Immunol. 2010 Feb;22(1):20-7. doi: 10.1016/j.coi.2009.12.002. Epub 2010 Jan 7. Curr Opin Immunol. 2010. PMID: 20060278 Review.

9

Regulators of TLR4 signaling by endotoxins.

McGettrick AF, O'Neill LA. McGettrick AF, et al. Subcell Biochem. 2010;53:153-71. doi: 10.1007/978-90-481-9078-2_7. Subcell Biochem. 2010. PMID: 20593266 Review.

10

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.

Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nuñez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA. Masters SL, et al. Nat Immunol. 2010 Oct;11(10):897-904. doi: 10.1038/ni.1935. Epub 2010 Sep 12. Nat Immunol. 2010. PMID: 20835230 Free PMC article.

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