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Isolevuglandin-type lipid aldehydes induce the inflammatory response of macrophages by modifying phosphatidylethanolamines and activating the receptor for advanced glycation endproducts.
Guo L, Chen Z, Amarnath V, Yancey PG, Van Lenten BJ, Savage JR, Fazio S, Linton MF, Davies SS. Guo L, et al. Among authors: amarnath v. Antioxid Redox Signal. 2015 Jun 20;22(18):1633-45. doi: 10.1089/ars.2014.6078. Epub 2015 Mar 18. Antioxid Redox Signal. 2015. PMID: 25751734 Free PMC article.
First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers.
Pitchford LM, Rathmacher JA, Fuller JC Jr, Daniels JS, Morrison RD, Akers WS, Abumrad NN, Amarnath V, Currey PM, Roberts LJ, Oates JA, Boutaud O. Pitchford LM, et al. Among authors: amarnath v. BMC Pharmacol Toxicol. 2019 Jan 5;20(1):1. doi: 10.1186/s40360-018-0281-7. BMC Pharmacol Toxicol. 2019. PMID: 30611293 Free PMC article. Clinical Trial.
Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia.
May-Zhang LS, Yermalitsky V, Melchior JT, Morris J, Tallman KA, Borja MS, Pleasent T, Amarnath V, Song W, Yancey PG, Davidson WS, Linton MF, Davies SS. May-Zhang LS, et al. Among authors: amarnath v. J Biol Chem. 2019 Dec 13;294(50):19022-19033. doi: 10.1074/jbc.RA119.009424. Epub 2019 Oct 30. J Biol Chem. 2019. PMID: 31666337 Free PMC article.
Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial.
Pitchford LM, Driver PM, Fuller JC Jr, Akers WS, Abumrad NN, Amarnath V, Milne GL, Chen SC, Ye F, Roberts LJ 2nd, Shoemaker MB, Oates JA, Rathmacher JA, Boutaud O. Pitchford LM, et al. Among authors: amarnath v. BMC Pharmacol Toxicol. 2020 Jan 6;21(1):3. doi: 10.1186/s40360-020-0382-y. BMC Pharmacol Toxicol. 2020. PMID: 31907026 Free PMC article. Clinical Trial.
Mitochondrial Isolevuglandins Contribute to Vascular Oxidative Stress and Mitochondria-Targeted Scavenger of Isolevuglandins Reduces Mitochondrial Dysfunction and Hypertension.
Dikalova A, Mayorov V, Xiao L, Panov A, Amarnath V, Zagol-Ikapitte I, Vergeade A, Ao M, Yermalitsky V, Nazarewicz RR, Boutaud O, Lopez MG, Billings FT 4th, Davies S, Roberts LJ 2nd, Harrison DG, Dikalov S. Dikalova A, et al. Among authors: amarnath v. Hypertension. 2020 Dec;76(6):1980-1991. doi: 10.1161/HYPERTENSIONAHA.120.15236. Epub 2020 Oct 5. Hypertension. 2020. PMID: 33012204 Free PMC article.
113 results