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A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant.
Jones A, Barker-Haliski M, Ilie AS, Herd MB, Baxendale S, Holdsworth CJ, Ashton JP, Placzek M, Jayasekera BAP, Cowie CJA, Lambert JJ, Trevelyan AJ, White HS, Marson AG, Cunliffe VT, Sills GJ, Morgan A. Jones A, et al. Among authors: morgan a. Epilepsia. 2020 Oct;61(10):2106-2118. doi: 10.1111/epi.16644. Epub 2020 Aug 14. Epilepsia. 2020. PMID: 32797628 Free PMC article.
Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.
Kashyap SS, Johnson JR, McCue HV, Chen X, Edmonds MJ, Ayala M, Graham ME, Jenn RC, Barclay JW, Burgoyne RD, Morgan A. Kashyap SS, et al. Among authors: morgan a. Hum Mol Genet. 2014 Nov 15;23(22):5916-27. doi: 10.1093/hmg/ddu316. Epub 2014 Jun 19. Hum Mol Genet. 2014. PMID: 24947438 Free PMC article.
3,432 results