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Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity.
Young BE, Ong SWX, Ng LFP, Anderson DE, Chia WN, Chia PY, Ang LW, Mak TM, Kalimuddin S, Chai LYA, Pada S, Tan SY, Sun L, Parthasarathy P, Fong SW, Chan YH, Tan CW, Lee B, Rötzschke O, Ding Y, Tambyah P, Low JGH, Cui L, Barkham T, Lin RTP, Leo YS, Renia L, Wang LF, Lye DC; Singapore 2019 Novel Coronavirus Outbreak Research Team. Young BE, et al. Among authors: rotzschke o. Clin Infect Dis. 2021 Nov 2;73(9):e2932-e2942. doi: 10.1093/cid/ciaa1280. Clin Infect Dis. 2021. PMID: 32856707 Free PMC article.
Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19.
Carissimo G, Xu W, Kwok I, Abdad MY, Chan YH, Fong SW, Puan KJ, Lee CY, Yeo NK, Amrun SN, Chee RS, How W, Chan S, Fan BE, Andiappan AK, Lee B, Rötzschke O, Young BE, Leo YS, Lye DC, Renia L, Ng LG, Larbi A, Ng LF. Carissimo G, et al. Among authors: rotzschke o. Nat Commun. 2020 Oct 16;11(1):5243. doi: 10.1038/s41467-020-19080-6. Nat Commun. 2020. PMID: 33067472 Free PMC article.
Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals.
Lim J, Puan KJ, Wang LW, Teng KWW, Loh CY, Tan KP, Carissimo G, Chan YH, Poh CM, Lee CY, Fong SW, Yeo NK, Chee RS, Amrun SN, Chang ZW, Tay MZ, Torres-Ruesta A, Leo Fernandez N, How W, Andiappan AK, Lee W, Duan K, Tan SY, Yan G, Kalimuddin S, Lye DC, Leo YS, Ong SWX, Young BE, Renia L, Ng LFP, Lee B, Rötzschke O. Lim J, et al. Among authors: rotzschke o. Front Immunol. 2021 Nov 19;12:710217. doi: 10.3389/fimmu.2021.710217. eCollection 2021. Front Immunol. 2021. PMID: 34867943 Free PMC article.
Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2.
Chan YH, Fong SW, Poh CM, Carissimo G, Yeo NK, Amrun SN, Goh YS, Lim J, Xu W, Chee RS, Torres-Ruesta A, Lee CY, Tay MZ, Chang ZW, Lee WH, Wang B, Tan SY, Kalimuddin S, Young BE, Leo YS, Wang CI, Lee B, Rötzschke O, Lye DC, Renia L, Ng LFP. Chan YH, et al. Among authors: rotzschke o. EMBO Mol Med. 2021 Jun 7;13(6):e14045. doi: 10.15252/emmm.202114045. Epub 2021 May 27. EMBO Mol Med. 2021. PMID: 33961735 Free PMC article.
Fingolimod treatment abrogates chikungunya virus-induced arthralgia.
Teo TH, Chan YH, Lee WW, Lum FM, Amrun SN, Her Z, Rajarethinam R, Merits A, Rötzschke O, Rénia L, Ng LF. Teo TH, et al. Among authors: rotzschke o. Sci Transl Med. 2017 Feb 1;9(375):eaal1333. doi: 10.1126/scitranslmed.aal1333. Sci Transl Med. 2017. PMID: 28148838
Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein.
Kam YW, Lum FM, Teo TH, Lee WW, Simarmata D, Harjanto S, Chua CL, Chan YF, Wee JK, Chow A, Lin RT, Leo YS, Le Grand R, Sam IC, Tong JC, Roques P, Wiesmüller KH, Rénia L, Rötzschke O, Ng LF. Kam YW, et al. Among authors: rotzschke o. EMBO Mol Med. 2012 Apr;4(4):330-43. doi: 10.1002/emmm.201200213. Epub 2012 Mar 5. EMBO Mol Med. 2012. PMID: 22389221 Free PMC article.
A Co-culture Model of PBMC and Stem Cell Derived Human Nasal Epithelium Reveals Rapid Activation of NK and Innate T Cells Upon Influenza A Virus Infection of the Nasal Epithelium.
Luukkainen A, Puan KJ, Yusof N, Lee B, Tan KS, Liu J, Yan Y, Toppila-Salmi S, Renkonen R, Chow VT, Rotzschke O, Wang Y. Luukkainen A, et al. Among authors: rotzschke o. Front Immunol. 2018 Nov 8;9:2514. doi: 10.3389/fimmu.2018.02514. eCollection 2018. Front Immunol. 2018. PMID: 30467502 Free PMC article.
147 results