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Page 1
Development of a pro-arrhythmic ex vivo intact human and porcine model: cardiac electrophysiological changes associated with cellular uncoupling.
Brook J, Kim MY, Koutsoftidis S, Pitcher D, Agha-Jaffar D, Sufi A, Jenkins C, Tzortzis K, Ma S, Jabbour RJ, Houston C, Handa BS, Li X, Chow JJ, Jothidasan A, Bristow P, Perkins J, Harding S, Bharath AA, Ng FS, Peters NS, Cantwell CD, Chowdhury RA. Brook J, et al. Among authors: tzortzis k. Pflugers Arch. 2020 Oct;472(10):1435-1446. doi: 10.1007/s00424-020-02446-6. Epub 2020 Sep 1. Pflugers Arch. 2020. PMID: 32870378 Free PMC article.
OCT2013, an ischaemia-activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine.
Hesketh LM, Sikkel MB, Mahoney-Sanchez L, Mazzacuva F, Chowdhury RA, Tzortzis KN, Firth J, Winter J, MacLeod KT, Ogrodzinski S, Wilder CDE, Patterson LH, Peters NS, Curtis MJ. Hesketh LM, et al. Among authors: tzortzis kn. Br J Pharmacol. 2022 May;179(9):2037-2053. doi: 10.1111/bph.15764. Epub 2022 Jan 13. Br J Pharmacol. 2022. PMID: 34855992 Free article.
Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device - the SERCA-LVAD TRIAL.
Lyon AR, Babalis D, Morley-Smith AC, Hedger M, Suarez Barrientos A, Foldes G, Couch LS, Chowdhury RA, Tzortzis KN, Peters NS, Rog-Zielinska EA, Yang HY, Welch S, Bowles CT, Rahman Haley S, Bell AR, Rice A, Sasikaran T, Johnson NA, Falaschetti E, Parameshwar J, Lewis C, Tsui S, Simon A, Pepper J, Rudy JJ, Zsebo KM, Macleod KT, Terracciano CM, Hajjar RJ, Banner N, Harding SE. Lyon AR, et al. Among authors: tzortzis kn. Gene Ther. 2020 Dec;27(12):579-590. doi: 10.1038/s41434-020-0171-7. Epub 2020 Jul 15. Gene Ther. 2020. PMID: 32669717 Free PMC article. Clinical Trial.
Nuclear proteasomes carry a constitutive posttranslational modification which derails SDS-PAGE (but not CTAB-PAGE).
Pitcher DS, de Mattos-Shipley K, Wang Z, Tzortzis K, Goudevenou K, Flynn H, Bohn G, Rahemtulla A, Roberts I, Snijders AP, Karadimitris A, Kleijnen MF. Pitcher DS, et al. Among authors: tzortzis k. Biochim Biophys Acta. 2014 Dec;1844(12):2222-8. doi: 10.1016/j.bbapap.2014.08.013. Epub 2014 Sep 2. Biochim Biophys Acta. 2014. PMID: 25192768 Free article.