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A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation.
Böhm S, Splith V, Riedmayr LM, Rötzer RD, Gasparoni G, Nordström KJV, Wagner JE, Hinrichsmeyer KS, Walter J, Wahl-Schott C, Fenske S, Biel M, Michalakis S, Becirovic E. Böhm S, et al. Among authors: walter j. Sci Adv. 2020 Aug 19;6(34):eaba5614. doi: 10.1126/sciadv.aba5614. eCollection 2020 Aug. Sci Adv. 2020. PMID: 32875106 Free PMC article.
Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction.
Schmidt F, Gasparoni N, Gasparoni G, Gianmoena K, Cadenas C, Polansky JK, Ebert P, Nordström K, Barann M, Sinha A, Fröhler S, Xiong J, Dehghani Amirabad A, Behjati Ardakani F, Hutter B, Zipprich G, Felder B, Eils J, Brors B, Chen W, Hengstler JG, Hamann A, Lengauer T, Rosenstiel P, Walter J, Schulz MH. Schmidt F, et al. Among authors: walter j. Nucleic Acids Res. 2017 Jan 9;45(1):54-66. doi: 10.1093/nar/gkw1061. Epub 2016 Nov 29. Nucleic Acids Res. 2017. PMID: 27899623 Free PMC article.
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex.
Gasparoni G, Bultmann S, Lutsik P, Kraus TFJ, Sordon S, Vlcek J, Dietinger V, Steinmaurer M, Haider M, Mulholland CB, Arzberger T, Roeber S, Riemenschneider M, Kretzschmar HA, Giese A, Leonhardt H, Walter J. Gasparoni G, et al. Among authors: walter j. Epigenetics Chromatin. 2018 Jul 25;11(1):41. doi: 10.1186/s13072-018-0211-3. Epigenetics Chromatin. 2018. PMID: 30045751 Free PMC article.
A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains.
Salhab A, Nordström K, Gasparoni G, Kattler K, Ebert P, Ramirez F, Arrigoni L, Müller F, Polansky JK, Cadenas C, G Hengstler J, Lengauer T, Manke T; DEEP Consortium; Walter J. Salhab A, et al. Among authors: walter j. Genome Biol. 2018 Sep 28;19(1):150. doi: 10.1186/s13059-018-1510-5. Genome Biol. 2018. PMID: 30266094 Free PMC article.
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control.
Brosch M, Kattler K, Herrmann A, von Schönfels W, Nordström K, Seehofer D, Damm G, Becker T, Zeissig S, Nehring S, Reichel F, Moser V, Thangapandi RV, Stickel F, Baretton G, Röcken C, Muders M, Matz-Soja M, Krawczak M, Gasparoni G, Hartmann H, Dahl A, Schafmayer C, Walter J, Hampe J. Brosch M, et al. Among authors: walter j. Nat Commun. 2018 Oct 8;9(1):4150. doi: 10.1038/s41467-018-06611-5. Nat Commun. 2018. PMID: 30297808 Free PMC article.
2,652 results