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Mitochondrial-derived peptides in aging and age-related diseases.
Kim SJ, Miller B, Kumagai H, Silverstein AR, Flores M, Yen K. Kim SJ, et al. Among authors: kumagai h. Geroscience. 2021 Jun;43(3):1113-1121. doi: 10.1007/s11357-020-00262-5. Epub 2020 Sep 10. Geroscience. 2021. PMID: 32910336 Free PMC article. Review.
MOTS-c: an equal opportunity insulin sensitizer.
Kim SJ, Miller B, Kumagai H, Yen K, Cohen P. Kim SJ, et al. Among authors: kumagai h. J Mol Med (Berl). 2019 Apr;97(4):487-490. doi: 10.1007/s00109-019-01758-0. Epub 2019 Feb 20. J Mol Med (Berl). 2019. PMID: 30788534 Free PMC article. No abstract available.
Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition.
D'Souza RF, Woodhead JST, Hedges CP, Zeng N, Wan J, Kumagai H, Lee C, Cohen P, Cameron-Smith D, Mitchell CJ, Merry TL. D'Souza RF, et al. Among authors: kumagai h. Aging (Albany NY). 2020 Mar 17;12(6):5244-5258. doi: 10.18632/aging.102944. Epub 2020 Mar 17. Aging (Albany NY). 2020. PMID: 32182209 Free PMC article.
Mitochondrial-derived peptides in energy metabolism.
Merry TL, Chan A, Woodhead JST, Reynolds JC, Kumagai H, Kim SJ, Lee C. Merry TL, et al. Among authors: kumagai h. Am J Physiol Endocrinol Metab. 2020 Oct 1;319(4):E659-E666. doi: 10.1152/ajpendo.00249.2020. Epub 2020 Aug 10. Am J Physiol Endocrinol Metab. 2020. PMID: 32776825 Free PMC article. Review.
A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.
Zempo H, Kim SJ, Fuku N, Nishida Y, Higaki Y, Wan J, Yen K, Miller B, Vicinanza R, Miyamoto-Mikami E, Kumagai H, Naito H, Xiao J, Mehta HH, Lee C, Hara M, Patel YM, Setiawan VW, Moore TM, Hevener AL, Sutoh Y, Shimizu A, Kojima K, Kinoshita K, Arai Y, Hirose N, Maeda S, Tanaka K, Cohen P. Zempo H, et al. Among authors: kumagai h. Aging (Albany NY). 2021 Jan 19;13(2):1692-1717. doi: 10.18632/aging.202529. Epub 2021 Jan 19. Aging (Albany NY). 2021. PMID: 33468709 Free PMC article.
MOTS-c reduces myostatin and muscle atrophy signaling.
Kumagai H, Coelho AR, Wan J, Mehta HH, Yen K, Huang A, Zempo H, Fuku N, Maeda S, Oliveira PJ, Cohen P, Kim SJ. Kumagai H, et al. Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E680-E690. doi: 10.1152/ajpendo.00275.2020. Epub 2021 Feb 8. Am J Physiol Endocrinol Metab. 2021. PMID: 33554779 Free PMC article.
1,253 results