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11 results

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Page 1
Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis.
John AE, Graves RH, Pun KT, Vitulli G, Forty EJ, Mercer PF, Morrell JL, Barrett JW, Rogers RF, Hafeji M, Bibby LI, Gower E, Morrison VS, Man Y, Roper JA, Luckett JC, Borthwick LA, Barksby BS, Burgoyne RA, Barnes R, Le J, Flint DJ, Pyne S, Habgood A, Organ LA, Joseph C, Edwards-Pritchard RC, Maher TM, Fisher AJ, Gudmann NS, Leeming DJ, Chambers RC, Lukey PT, Marshall RP, Macdonald SJF, Jenkins RG, Slack RJ. John AE, et al. Among authors: graves rh. Nat Commun. 2020 Sep 16;11(1):4659. doi: 10.1038/s41467-020-18397-6. Nat Commun. 2020. PMID: 32938936 Free PMC article.
Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.
Procopiou PA, Barrett JW, Barton NP, Begg M, Clapham D, Copley RC, Ford AJ, Graves RH, Hall DA, Hancock AP, Hill AP, Hobbs H, Hodgson ST, Jumeaux C, Lacroix YM, Miah AH, Morriss KM, Needham D, Sheriff EB, Slack RJ, Smith CE, Sollis SL, Staton H. Procopiou PA, et al. Among authors: graves rh. J Med Chem. 2013 Mar 14;56(5):1946-60. doi: 10.1021/jm301572h. Epub 2013 Feb 27. J Med Chem. 2013. PMID: 23409871
Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket.
Harling JD, Deakin AM, Campos S, Grimley R, Chaudry L, Nye C, Polyakova O, Bessant CM, Barton N, Somers D, Barrett J, Graves RH, Hanns L, Kerr WJ, Solari R. Harling JD, et al. Among authors: graves rh. J Biol Chem. 2013 Sep 27;288(39):28195-206. doi: 10.1074/jbc.M113.474114. Epub 2013 Aug 9. J Biol Chem. 2013. PMID: 23935099 Free PMC article.
Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.
Miller NA, Graves RH, Edwards CD, Amour A, Taylor E, Robb O, O'Brien B, Patel A, Harrell AW, Hessel EM. Miller NA, et al. Among authors: graves rh. Clin Pharmacokinet. 2022 Feb;61(2):281-293. doi: 10.1007/s40262-021-01066-2. Epub 2021 Aug 30. Clin Pharmacokinet. 2022. PMID: 34458976 Free PMC article.
Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study.
Cahn A, Hodgson S, Wilson R, Robertson J, Watson J, Beerahee M, Hughes SC, Young G, Graves R, Hall D, van Marle S, Solari R. Cahn A, et al. BMC Pharmacol Toxicol. 2013 Feb 28;14:14. doi: 10.1186/2050-6511-14-14. BMC Pharmacol Toxicol. 2013. PMID: 23448278 Free PMC article. Clinical Trial.
Interaction of oral phenytoin with enteral feedings.
Saklad JJ, Graves RH, Sharp WP. Saklad JJ, et al. Among authors: graves rh. JPEN J Parenter Enteral Nutr. 1986 May-Jun;10(3):322-3. doi: 10.1177/0148607186010003322. JPEN J Parenter Enteral Nutr. 1986. PMID: 3086593
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