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Phosphodiesterase 4 inhibitor and phosphodiesterase 5 inhibitor combination therapy has antifibrotic and anti-inflammatory effects in mdx mice with Duchenne muscular dystrophy.
Nio Y, Tanaka M, Hirozane Y, Muraki Y, Okawara M, Hazama M, Matsuo T. Nio Y, et al. Among authors: hazama m. FASEB J. 2017 Dec;31(12):5307-5320. doi: 10.1096/fj.201700249R. Epub 2017 Aug 10. FASEB J. 2017. PMID: 28798156
In summary, we confirmed that piclamilast has significant antifibrotic effects in mdx mouse muscle and is a potential treatment for muscle fibrosis in DMD.-Nio, Y., Tanaka, M., Hirozane, Y., Muraki, Y., Okawara, M., Hazama, M., Matsuo, T. Phosphodieste …
In summary, we confirmed that piclamilast has significant antifibrotic effects in mdx mouse muscle and is a potential treatment for muscle f …
Improvement of pulmonary arterial hypertension, inflammatory response, and epithelium injury by dual activation of cAMP/cGMP pathway in a rat model of monocrotaline-induced pulmonary hypertension.
Muraki Y, Naito T, Tohyama K, Shibata S, Kuniyeda K, Nio Y, Hazama M, Matsuo T. Muraki Y, et al. Among authors: hazama m. Biosci Biotechnol Biochem. 2019 Jun;83(6):1000-1010. doi: 10.1080/09168451.2019.1584520. Epub 2019 Mar 5. Biosci Biotechnol Biochem. 2019. PMID: 30835622
Putative pheromone receptors related to the Ca2+-sensing receptor in Fugu.
Naito T, Saito Y, Yamamoto J, Nozaki Y, Tomura K, Hazama M, Nakanishi S, Brenner S. Naito T, et al. Among authors: hazama m. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5178-81. doi: 10.1073/pnas.95.9.5178. Proc Natl Acad Sci U S A. 1998. PMID: 9560249 Free PMC article.
Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes.
Banno Y, Sasaki S, Kamata M, Kunitomo J, Miyamoto Y, Abe H, Taya N, Oi S, Watanabe M, Urushibara T, Hazama M, Niwa SI, Miyamoto S, Horinouchi A, Kuroshima KI, Amano N, Matsumoto SI, Matsunaga S. Banno Y, et al. Among authors: hazama m. Bioorg Med Chem. 2017 Nov 1;25(21):5995-6006. doi: 10.1016/j.bmc.2017.09.031. Epub 2017 Sep 21. Bioorg Med Chem. 2017. PMID: 28988629
94 results