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Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens.
Scharschmidt TC, Man MQ, Hatano Y, Crumrine D, Gunathilake R, Sundberg JP, Silva KA, Mauro TM, Hupe M, Cho S, Wu Y, Celli A, Schmuth M, Feingold KR, Elias PM. Scharschmidt TC, et al. Among authors: celli a. J Allergy Clin Immunol. 2009 Sep;124(3):496-506, 506.e1-6. doi: 10.1016/j.jaci.2009.06.046. J Allergy Clin Immunol. 2009. PMID: 19733297 Free PMC article.
Tight junction properties change during epidermis development.
Celli A, Zhai Y, Jiang YJ, Crumrine D, Elias PM, Feingold KR, Mauro TM. Celli A, et al. Exp Dermatol. 2012 Oct;21(10):798-801. doi: 10.1111/j.1600-0625.2012.01573.x. Epub 2012 Aug 7. Exp Dermatol. 2012. PMID: 22882565 Free PMC article.
158 results