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Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to drive breast cancer development.
Song K, Cai X, Dong Y, Wu H, Wei Y, Shankavaram UT, Cui K, Lee Y, Zhu B, Bhattacharjee S, Wang B, Zhang K, Wen A, Wong S, Yu L, Xia L, Welm AL, Bielenberg DR, Camphausen KA, Kang Y, Chen H. Song K, et al. Among authors: xia l. J Clin Invest. 2021 Jan 4;131(1):e129374. doi: 10.1172/JCI129374. J Clin Invest. 2021. PMID: 32960814 Free PMC article.
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice.
Fu J, Wei B, Wen T, Johansson ME, Liu X, Bradford E, Thomsson KA, McGee S, Mansour L, Tong M, McDaniel JM, Sferra TJ, Turner JR, Chen H, Hansson GC, Braun J, Xia L. Fu J, et al. Among authors: xia l. J Clin Invest. 2011 Apr;121(4):1657-66. doi: 10.1172/JCI45538. Epub 2011 Mar 7. J Clin Invest. 2011. PMID: 21383503 Free PMC article.
Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling.
Pasula S, Cai X, Dong Y, Messa M, McManus J, Chang B, Liu X, Zhu H, Mansat RS, Yoon SJ, Hahn S, Keeling J, Saunders D, Ko G, Knight J, Newton G, Luscinskas F, Sun X, Towner R, Lupu F, Xia L, Cremona O, De Camilli P, Min W, Chen H. Pasula S, et al. Among authors: xia l. J Clin Invest. 2012 Dec;122(12):4424-38. doi: 10.1172/JCI64537. Epub 2012 Nov 26. J Clin Invest. 2012. PMID: 23187125 Free PMC article.
Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by epsin deficiency.
Tessneer KL, Pasula S, Cai X, Dong Y, McManus J, Liu X, Yu L, Hahn S, Chang B, Chen Y, Griffin C, Xia L, Adams RH, Chen H. Tessneer KL, et al. Among authors: xia l. Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):331-337. doi: 10.1161/ATVBAHA.113.302586. Epub 2013 Dec 5. Arterioscler Thromb Vasc Biol. 2014. PMID: 24311377 Free PMC article.
Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function.
Liu X, Pasula S, Song H, Tessneer KL, Dong Y, Hahn S, Yago T, Brophy ML, Chang B, Cai X, Wu H, McManus J, Ichise H, Georgescu C, Wren JD, Griffin C, Xia L, Srinivasan RS, Chen H. Liu X, et al. Among authors: xia l. Sci Signal. 2014 Oct 14;7(347):ra97. doi: 10.1126/scisignal.2005413. Sci Signal. 2014. PMID: 25314967 Free PMC article.
Loss of Core 1-derived O-Glycans Decreases Breast Cancer Development in Mice.
Song K, Herzog BH, Fu J, Sheng M, Bergstrom K, McDaniel JM, Kondo Y, McGee S, Cai X, Li P, Chen H, Xia L. Song K, et al. Among authors: xia l. J Biol Chem. 2015 Aug 14;290(33):20159-66. doi: 10.1074/jbc.M115.654483. Epub 2015 Jun 29. J Biol Chem. 2015. PMID: 26124270 Free PMC article.
6,731 results