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Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.
Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. Sundaram A, et al. Among authors: sheppard d. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127578. doi: 10.1016/j.bmcl.2020.127578. Epub 2020 Sep 29. Bioorg Med Chem Lett. 2020. PMID: 33007395 Free PMC article.
Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.
Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D. Chen C, et al. Among authors: sheppard d. J Clin Invest. 2012 Aug;122(8):2916-27. doi: 10.1172/JCI60387. Epub 2012 Jul 9. J Clin Invest. 2012. PMID: 22772469 Free PMC article.
The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.
Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. Katsumoto TR, et al. Among authors: sheppard d. J Clin Invest. 2013 May;123(5):2037-48. doi: 10.1172/JCI66397. Epub 2013 Apr 1. J Clin Invest. 2013. PMID: 23543053 Free PMC article.
The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.
Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. Reed NI, et al. Among authors: sheppard d. Sci Transl Med. 2015 May 20;7(288):288ra79. doi: 10.1126/scitranslmed.aaa5094. Sci Transl Med. 2015. PMID: 25995225 Free PMC article.
918 results