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MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.
Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, Bai W. Fu W, et al. Among authors: zhang m, zhang x, zhang y. J Biol Chem. 2009 May 22;284(21):13987-4000. doi: 10.1074/jbc.M901758200. Epub 2009 Mar 25. J Biol Chem. 2009. PMID: 19321440 Free PMC article.
Bing De Ling, a Chinese herbal formula, inhibits cancer cells growth via p53.
Zhang Y, Dong H, Li Z, Xiang S, Zhu Y, Zhang M, Liu J, Bai W, Nicosia SV, Chen J, Zhao RJ, Zhang X. Zhang Y, et al. Among authors: zhang m, zhang x. Front Biosci (Elite Ed). 2010 Jan 1;2(1):221-30. doi: 10.2741/e84. Front Biosci (Elite Ed). 2010. PMID: 20036872 Free article.
Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration.
Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, Ryan M, Cox AD, Der CJ, Fang B, Koomen J, Haura E, Bepler G, Nicosia SV, Matthias P, Wang C, Bai W, Zhang X. Williams KA, et al. Among authors: zhang m, zhang s, zhang x. J Biol Chem. 2013 Nov 15;288(46):33156-70. doi: 10.1074/jbc.M113.472506. Epub 2013 Oct 2. J Biol Chem. 2013. PMID: 24089523 Free PMC article.
HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα.
Zhang M, Xiang S, Joo HY, Wang L, Williams KA, Liu W, Hu C, Tong D, Haakenson J, Wang C, Zhang S, Pavlovicz RE, Jones A, Schmidt KH, Tang J, Dong H, Shan B, Fang B, Radhakrishnan R, Glazer PM, Matthias P, Koomen J, Seto E, Bepler G, Nicosia SV, Chen J, Li C, Gu L, Li GM, Bai W, Wang H, Zhang X. Zhang M, et al. Among authors: zhang s, zhang x. Mol Cell. 2014 Jul 3;55(1):31-46. doi: 10.1016/j.molcel.2014.04.028. Epub 2014 May 29. Mol Cell. 2014. PMID: 24882211 Free PMC article.
HDAC6 regulates DNA damage response via deacetylating MLH1.
Zhang M, Hu C, Moses N, Haakenson J, Xiang S, Quan D, Fang B, Yang Z, Bai W, Bepler G, Li GM, Zhang XM. Zhang M, et al. Among authors: zhang xm. J Biol Chem. 2019 Apr 12;294(15):5813-5826. doi: 10.1074/jbc.RA118.006374. Epub 2019 Feb 15. J Biol Chem. 2019. PMID: 30770470 Free PMC article.
FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis.
Mitchell AV, Wu L, James Block C, Zhang M, Hackett J, Craig DB, Chen W, Zhao Y, Zhang B, Dang Y, Zhang X, Zhang S, Wang C, Gibson H, Pile LA, Kidder B, Matherly L, Yang Z, Dou Y, Wu G. Mitchell AV, et al. Among authors: zhang m, zhang b, zhang s, zhang x. Nat Commun. 2022 Nov 1;13(1):6548. doi: 10.1038/s41467-022-34239-z. Nat Commun. 2022. PMID: 36319643 Free PMC article.
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