Clemente F - Search Results

1

Synthesis of "All-Cis" Trihydroxypiperidines from a Carbohydrate-Derived Ketone: Hints for the Design of New β-Gal and GCase Inhibitors.

Davighi MG, Clemente F, Matassini C, Morrone A, Goti A, Martínez-Bailén M, Cardona F. Davighi MG, et al. Among authors: clemente f. Molecules. 2020 Oct 2;25(19):4526. doi: 10.3390/molecules25194526. Molecules. 2020. PMID: 33023214 Free PMC article.

2

Stereoselective Synthesis of C-2 Alkylated Trihydroxypiperidines: Novel Pharmacological Chaperones for Gaucher Disease.

Clemente F, Matassini C, Goti A, Morrone A, Paoli P, Cardona F. Clemente F, et al. ACS Med Chem Lett. 2019 Feb 8;10(4):621-626. doi: 10.1021/acsmedchemlett.8b00602. eCollection 2019 Apr 11. ACS Med Chem Lett. 2019. PMID: 30996807 Free PMC article.

3

Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning.

Clemente F, Matassini C, Faggi C, Giachetti S, Cresti C, Morrone A, Paoli P, Goti A, Martínez-Bailén M, Cardona F. Clemente F, et al. Bioorg Chem. 2020 May;98:103740. doi: 10.1016/j.bioorg.2020.103740. Epub 2020 Mar 9. Bioorg Chem. 2020. PMID: 32200326

4

Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase).

Clemente F, Matassini C, Giachetti S, Goti A, Morrone A, Martínez-Bailén M, Orta S, Merino P, Cardona F. Clemente F, et al. J Org Chem. 2021 Sep 17;86(18):12745-12761. doi: 10.1021/acs.joc.1c01308. Epub 2021 Sep 1. J Org Chem. 2021. PMID: 34469155 Free PMC article.

5

Photoswitchable inhibitors of human β-glucocerebrosidase.

Davighi MG, Clemente F, Matassini C, Cardona F, Nielsen MB, Goti A, Morrone A, Paoli P, Cacciarini M. Davighi MG, et al. Among authors: clemente f. Org Biomol Chem. 2022 Feb 23;20(8):1637-1641. doi: 10.1039/d1ob02159a. Org Biomol Chem. 2022. PMID: 35107482

6

3,4,5-Trihydroxypiperidine Based Multivalent Glucocerebrosidase (GCase) Enhancers.

Vanni C, Clemente F, Paoli P, Morrone A, Matassini C, Goti A, Cardona F. Vanni C, et al. Among authors: clemente f. Chembiochem. 2022 Jun 3;23(11):e202200077. doi: 10.1002/cbic.202200077. Epub 2022 Apr 7. Chembiochem. 2022. PMID: 35322924 Free PMC article.

7

Synthesis of a New β-Galactosidase Inhibitor Displaying Pharmacological Chaperone Properties for GM1 Gangliosidosis.

Clemente F, Martínez-Bailén M, Matassini C, Morrone A, Falliano S, Caciotti A, Paoli P, Goti A, Cardona F. Clemente F, et al. Molecules. 2022 Jun 22;27(13):4008. doi: 10.3390/molecules27134008. Molecules. 2022. PMID: 35807262 Free PMC article.

8

GCase Enhancers: A Potential Therapeutic Option for Gaucher Disease and Other Neurological Disorders.

Martínez-Bailén M, Clemente F, Matassini C, Cardona F. Martínez-Bailén M, et al. Among authors: clemente f. Pharmaceuticals (Basel). 2022 Jul 2;15(7):823. doi: 10.3390/ph15070823. Pharmaceuticals (Basel). 2022. PMID: 35890122 Free PMC article. Review.

9

Light-Triggered Control of Glucocerebrosidase Inhibitors: Towards Photoswitchable Pharmacological Chaperones.

Clemente F, Davighi MG, Matassini C, Cardona F, Goti A, Morrone A, Paoli P, Tejero T, Merino P, Cacciarini M. Clemente F, et al. Chemistry. 2023 Apr 3;29(19):e202203841. doi: 10.1002/chem.202203841. Epub 2023 Mar 1. Chemistry. 2023. PMID: 36598148

10

Stereoselective Synthesis of Heavily Hydroxylated Azepane Iminosugars via Osmium-Catalyzed Tethered Aminohydroxylation.

Martínez-Bailén M, Matassini C, Clemente F, Faggi C, Goti A, Cardona F. Martínez-Bailén M, et al. Among authors: clemente f. Org Lett. 2023 Aug 11;25(31):5833-5837. doi: 10.1021/acs.orglett.3c02087. Epub 2023 Jul 29. Org Lett. 2023. PMID: 37515782 Free PMC article.

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