Medina-Carmona E - Search Results

1

Chagas Disease: Current View of an Ancient and Global Chemotherapy Challenge.

Martín-Escolano J, Medina-Carmona E, Martín-Escolano R. Martín-Escolano J, et al. Among authors: medina carmona e. ACS Infect Dis. 2020 Nov 13;6(11):2830-2843. doi: 10.1021/acsinfecdis.0c00353. Epub 2020 Oct 9. ACS Infect Dis. 2020. PMID: 33034192 Review.

2

Synthesis and Biological in vitro and in vivo Evaluation of 2-(5-Nitroindazol-1-yl)ethylamines and Related Compounds as Potential Therapeutic Alternatives for Chagas Disease.

Martín-Escolano R, Aguilera-Venegas B, Marín C, Martín-Montes Á, Martín-Escolano J, Medina-Carmona E, Arán VJ, Sánchez-Moreno M. Martín-Escolano R, et al. Among authors: medina carmona e. ChemMedChem. 2018 Oct 8;13(19):2104-2118. doi: 10.1002/cmdc.201800512. Epub 2018 Sep 4. ChemMedChem. 2018. PMID: 30098232 Free article.

3

New polyamine drugs as more effective antichagas agents than benznidazole in both the acute and chronic phases.

Martín-Escolano R, Molina-Carreño D, Delgado-Pinar E, Martin-Montes Á, Clares MP, Medina-Carmona E, Pitarch-Jarque J, Martín-Escolano J, Rosales MJ, García-España E, Sánchez-Moreno M, Marín C. Martín-Escolano R, et al. Among authors: medina carmona e. Eur J Med Chem. 2019 Feb 15;164:27-46. doi: 10.1016/j.ejmech.2018.12.034. Epub 2018 Dec 15. Eur J Med Chem. 2019. PMID: 30583247

4

An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment.

Martín-Escolano J, Marín C, Rosales MJ, Tsaousis AD, Medina-Carmona E, Martín-Escolano R. Martín-Escolano J, et al. Among authors: medina carmona e. ACS Infect Dis. 2022 Jun 10;8(6):1107-1115. doi: 10.1021/acsinfecdis.2c00123. Epub 2022 Jun 2. ACS Infect Dis. 2022. PMID: 35652513 Free PMC article. Review.

5

Second Generation of Mannich Base-Type Derivatives with in Vivo Activity against Trypanosoma cruzi.

Martín-Escolano R, Moreno-Viguri E, Santivañez-Veliz M, Martin-Montes A, Medina-Carmona E, Paucar R, Marín C, Azqueta A, Cirauqui N, Pey AL, Pérez-Silanes S, Sánchez-Moreno M. Martín-Escolano R, et al. J Med Chem. 2018 Jul 12;61(13):5643-5663. doi: 10.1021/acs.jmedchem.8b00468. Epub 2018 Jun 22. J Med Chem. 2018. PMID: 29883536

6

Synthesis and biological evaluation of new long-chain squaramides as anti-chagasic agents in the BALB/c mouse model.

Martín-Escolano R, Marín C, Vega M, Martin-Montes Á, Medina-Carmona E, López C, Rotger C, Costa A, Sánchez-Moreno M. Martín-Escolano R, et al. Among authors: medina carmona e. Bioorg Med Chem. 2019 Mar 1;27(5):865-879. doi: 10.1016/j.bmc.2019.01.033. Epub 2019 Jan 29. Bioorg Med Chem. 2019. PMID: 30728107

7

Phosphorylation compromises FAD binding and intracellular stability of wild-type and cancer-associated NQO1: Insights into flavo-proteome stability.

Medina-Carmona E, Rizzuti B, Martín-Escolano R, Pacheco-García JL, Mesa-Torres N, Neira JL, Guzzi R, Pey AL. Medina-Carmona E, et al. Int J Biol Macromol. 2019 Mar 15;125:1275-1288. doi: 10.1016/j.ijbiomac.2018.09.108. Epub 2018 Sep 19. Int J Biol Macromol. 2019. PMID: 30243998

8

A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R.

Muñoz IG, Morel B, Medina-Carmona E, Pey AL. Muñoz IG, et al. FEBS Lett. 2017 Sep;591(18):2826-2835. doi: 10.1002/1873-3468.12772. Epub 2017 Aug 20. FEBS Lett. 2017. PMID: 28771686 Free article.

9

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.

Medina-Carmona E, Palomino-Morales RJ, Fuchs JE, Padín-Gonzalez E, Mesa-Torres N, Salido E, Timson DJ, Pey AL. Medina-Carmona E, et al. Sci Rep. 2016 Feb 3;6:20331. doi: 10.1038/srep20331. Sci Rep. 2016. PMID: 26838129 Free PMC article.

10

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.

Medina-Carmona E, Neira JL, Salido E, Fuchs JE, Palomino-Morales R, Timson DJ, Pey AL. Medina-Carmona E, et al. Sci Rep. 2017 Mar 14;7:44532. doi: 10.1038/srep44532. Sci Rep. 2017. PMID: 28291250 Free PMC article.

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