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DeepC: predicting 3D genome folding using megabase-scale transfer learning.
Schwessinger R, Gosden M, Downes D, Brown RC, Oudelaar AM, Telenius J, Teh YW, Lunter G, Hughes JR. Schwessinger R, et al. Among authors: downes d. Nat Methods. 2020 Nov;17(11):1118-1124. doi: 10.1038/s41592-020-0960-3. Epub 2020 Oct 12. Nat Methods. 2020. PMID: 33046896 Free PMC article.
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.
Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D, Kerry J, Gosden M, Telenius J, Sloane-Stanley JA, Faustino P, Coelho A, Doondeea J, Usukhbayar B, Sopp P, Sharpe JA, Hughes JR, Vyas P, Gibbons RJ, Higgs DR. Mettananda S, et al. Among authors: downes d. Nat Commun. 2017 Sep 4;8(1):424. doi: 10.1038/s41467-017-00479-7. Nat Commun. 2017. PMID: 28871148 Free PMC article.
Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis.
Gillespie MA, Palii CG, Sanchez-Taltavull D, Shannon P, Longabaugh WJR, Downes DJ, Sivaraman K, Espinoza HM, Hughes JR, Price ND, Perkins TJ, Ranish JA, Brand M. Gillespie MA, et al. Among authors: downes dj. Mol Cell. 2020 Jun 4;78(5):960-974.e11. doi: 10.1016/j.molcel.2020.03.031. Epub 2020 Apr 23. Mol Cell. 2020. PMID: 32330456 Free PMC article.
87 results