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DeepC: predicting 3D genome folding using megabase-scale transfer learning.
Schwessinger R, Gosden M, Downes D, Brown RC, Oudelaar AM, Telenius J, Teh YW, Lunter G, Hughes JR. Schwessinger R, et al. Among authors: gosden m. Nat Methods. 2020 Nov;17(11):1118-1124. doi: 10.1038/s41592-020-0960-3. Epub 2020 Oct 12. Nat Methods. 2020. PMID: 33046896 Free PMC article.
Dynamics of the 4D genome during in vivo lineage specification and differentiation.
Oudelaar AM, Beagrie RA, Gosden M, de Ornellas S, Georgiades E, Kerry J, Hidalgo D, Carrelha J, Shivalingam A, El-Sagheer AH, Telenius JM, Brown T, Buckle VJ, Socolovsky M, Higgs DR, Hughes JR. Oudelaar AM, et al. Among authors: gosden m. Nat Commun. 2020 Jun 1;11(1):2722. doi: 10.1038/s41467-020-16598-7. Nat Commun. 2020. PMID: 32483172 Free PMC article.
High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale.
Downes DJ, Beagrie RA, Gosden ME, Telenius J, Carpenter SJ, Nussbaum L, De Ornellas S, Sergeant M, Eijsbouts CQ, Schwessinger R, Kerry J, Roberts N, Shivalingam A, El-Sagheer A, Oudelaar AM, Brown T, Buckle VJ, Davies JOJ, Hughes JR. Downes DJ, et al. Among authors: gosden me. Nat Commun. 2021 Jan 22;12(1):531. doi: 10.1038/s41467-020-20809-6. Nat Commun. 2021. PMID: 33483495 Free PMC article.
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.
Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D, Kerry J, Gosden M, Telenius J, Sloane-Stanley JA, Faustino P, Coelho A, Doondeea J, Usukhbayar B, Sopp P, Sharpe JA, Hughes JR, Vyas P, Gibbons RJ, Higgs DR. Mettananda S, et al. Among authors: gosden m. Nat Commun. 2017 Sep 4;8(1):424. doi: 10.1038/s41467-017-00479-7. Nat Commun. 2017. PMID: 28871148 Free PMC article.
Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities.
Scott C, Downes DJ, Brown JM, Beagrie R, Olijnik AA, Gosden M, Schwessinger R, Fisher CA, Rose A, Ferguson DJP, Johnson E, Hill QA, Okoli S, Renella R, Ryan K, Brand M, Hughes J, Roy NBA, Higgs DR, Babbs C, Buckle VJ. Scott C, et al. Among authors: gosden m. Haematologica. 2021 Nov 1;106(11):2960-2970. doi: 10.3324/haematol.2020.260158. Haematologica. 2021. PMID: 33121234 Free PMC article.
Scalable in vitro production of defined mouse erythroblasts.
Francis HS, Harold CL, Beagrie RA, King AJ, Gosden ME, Blayney JW, Jeziorska DM, Babbs C, Higgs DR, Kassouf MT. Francis HS, et al. Among authors: gosden me. PLoS One. 2022 Jan 7;17(1):e0261950. doi: 10.1371/journal.pone.0261950. eCollection 2022. PLoS One. 2022. PMID: 34995303 Free PMC article.
Analysis of Differentiation Protocols Defines a Common Pancreatic Progenitor Molecular Signature and Guides Refinement of Endocrine Differentiation.
Wesolowska-Andersen A, Jensen RR, Alcántara MP, Beer NL, Duff C, Nylander V, Gosden M, Witty L, Bowden R, McCarthy MI, Hansson M, Gloyn AL, Honore C. Wesolowska-Andersen A, et al. Among authors: gosden m. Stem Cell Reports. 2020 Jan 14;14(1):138-153. doi: 10.1016/j.stemcr.2019.11.010. Epub 2019 Dec 26. Stem Cell Reports. 2020. PMID: 31883919 Free PMC article.
16 results