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Dimers of DNA-PK create a stage for DNA double-strand break repair.
Chaplin AK, Hardwick SW, Liang S, Kefala Stavridi A, Hnizda A, Cooper LR, De Oliveira TM, Chirgadze DY, Blundell TL. Chaplin AK, et al. Nat Struct Mol Biol. 2021 Jan;28(1):13-19. doi: 10.1038/s41594-020-00517-x. Epub 2020 Oct 19. Nat Struct Mol Biol. 2021. PMID: 33077952
SAP domain forms a flexible part of DNA aperture in Ku70/80.
Hnízda A, Tesina P, Nguyen TB, Kukačka Z, Kater L, Chaplin AK, Beckmann R, Ascher DB, Novák P, Blundell TL. Hnízda A, et al. Among authors: chaplin ak. FEBS J. 2021 Jul;288(14):4382-4393. doi: 10.1111/febs.15732. Epub 2021 Feb 16. FEBS J. 2021. PMID: 33511782 Free PMC article.
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Chaplin AK, Hardwick SW, Stavridi AK, Buehl CJ, Goff NJ, Ropars V, Liang S, De Oliveira TM, Chirgadze DY, Meek K, Charbonnier JB, Blundell TL. Chaplin AK, et al. Mol Cell. 2021 Aug 19;81(16):3400-3409.e3. doi: 10.1016/j.molcel.2021.07.005. Epub 2021 Aug 4. Mol Cell. 2021. PMID: 34352203 Free PMC article.
35 results