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Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase.
McDonald G, Chubukov V, Coco J, Truskowski K, Narayanaswamy R, Choe S, Steadman M, Artin E, Padyana AK, Jin L, Ronseaux S, Locuson C, Fan ZP, Erdmann T, Mann A, Hayes S, Fletcher M, Nellore K, Rao SS, Subramanya H, Reddy KS, Panigrahi SK, Antony T, Gopinath S, Sui Z, Nagaraja N, Dang L, Lenz G, Hurov J, Biller SA, Murtie J, Marks KM, Ulanet DB. McDonald G, et al. Among authors: nellore k. Mol Cancer Ther. 2020 Dec;19(12):2502-2515. doi: 10.1158/1535-7163.MCT-20-0550. Epub 2020 Oct 20. Mol Cancer Ther. 2020. PMID: 33082276
Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH.
Abdullah I, Chee CF, Lee YK, Thunuguntla SSR, Satish Reddy K, Nellore K, Antony T, Verma J, Mun KW, Othman S, Subramanya H, Rahman NA. Abdullah I, et al. Among authors: nellore k. Bioorg Med Chem. 2015 Aug 1;23(15):4669-4680. doi: 10.1016/j.bmc.2015.05.051. Epub 2015 Jun 5. Bioorg Med Chem. 2015. PMID: 26088338
Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies.
Gummadi VR, Boruah A, Ainan BR, Vare BR, Manda S, Gondle HP, Kumar SN, Mukherjee S, Gore ST, Krishnamurthy NR, Marappan S, Nayak SS, Nellore K, Balasubramanian WR, Bhumireddy A, Giri S, Gopinath S, Samiulla DS, Daginakatte G, Basavaraju A, Chelur S, Eswarappa R, Belliappa C, Subramanya HS, Booher RN, Ramachandra M, Samajdar S. Gummadi VR, et al. Among authors: nellore k. ACS Med Chem Lett. 2020 Oct 14;11(12):2374-2381. doi: 10.1021/acsmedchemlett.0c00255. eCollection 2020 Dec 10. ACS Med Chem Lett. 2020. PMID: 33335659 Free PMC article.
Anticancer activity of Neptunia oleracea methanolic extracts.
Bhumireddy A, Nellore K, Alapati KS. Bhumireddy A, et al. Among authors: nellore k. Nat Prod Res. 2022 Feb;36(4):1053-1057. doi: 10.1080/14786419.2020.1844693. Epub 2020 Nov 20. Nat Prod Res. 2022. PMID: 33213226
Design, synthesis, and biological evaluation of phenyl thiazole-based AR-V7 degraders.
Bhumireddy A, Bandaru NVMR, Raghurami Reddy B, Gore ST, Mukherjee S, Balasubramanian WR, Sumanth Kumar V, Alapati KS, Venkata Gowri Chandra Sekhar K, Nellore K, Abbineni C, Samajdar S. Bhumireddy A, et al. Among authors: nellore k. Bioorg Med Chem Lett. 2022 Jan 1;55:128448. doi: 10.1016/j.bmcl.2021.128448. Epub 2021 Nov 9. Bioorg Med Chem Lett. 2022. PMID: 34767914
15 results