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Cystamine/cysteamine rescues the dopaminergic system and shows neurorestorative properties in an animal model of Parkinson's disease.
Cisbani G, Drouin-Ouellet J, Gibrat C, Saint-Pierre M, Lagacé M, Badrinarayanan S, Lavallée-Bourget MH, Charest J, Chabrat A, Boivin L, Lebel M, Bousquet M, Lévesque M, Cicchetti F. Cisbani G, et al. Among authors: levesque m. Neurobiol Dis. 2015 Oct;82:430-444. doi: 10.1016/j.nbd.2015.07.012. Epub 2015 Jul 29. Neurobiol Dis. 2015. PMID: 26232588
The Quebec Parkinson Network: A Researcher-Patient Matching Platform and Multimodal Biorepository.
Gan-Or Z, Rao T, Leveille E, Degroot C, Chouinard S, Cicchetti F, Dagher A, Das S, Desautels A, Drouin-Ouellet J, Durcan T, Gagnon JF, Genge A, Karamchandani J, Lafontaine AL, Sun SLW, Langlois M, Levesque M, Melmed C, Panisset M, Parent M, Poline JB, Postuma RB, Pourcher E, Rouleau GA, Sharp M, Monchi O, Dupré N, Fon EA. Gan-Or Z, et al. Among authors: levesque m. J Parkinsons Dis. 2020;10(1):301-313. doi: 10.3233/JPD-191775. J Parkinsons Dis. 2020. PMID: 31868683 Free PMC article.
A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease.
Bérard M, Sheta R, Malvaut S, Rodriguez-Aller R, Teixeira M, Idi W, Turmel R, Alpaugh M, Dubois M, Dahmene M, Salesse C, Lamontagne-Proulx J, St-Pierre MK, Tavassoly O, Luo W, Del Cid-Pellitero E, Qazi R, Jeong JW, Durcan TM, Vallières L, Tremblay ME, Soulet D, Lévesque M, Cicchetti F, Fon EA, Saghatelyan A, Oueslati A. Bérard M, et al. Among authors: levesque m. PLoS Biol. 2022 Mar 9;20(3):e3001578. doi: 10.1371/journal.pbio.3001578. eCollection 2022 Mar. PLoS Biol. 2022. PMID: 35263320 Free PMC article.
The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology.
Obergasteiger J, Castonguay AM, Pizzi S, Magnabosco S, Frapporti G, Lobbestael E, Baekelandt V, Hicks AA, Pramstaller PP, Gravel C, Corti C, Lévesque M, Volta M. Obergasteiger J, et al. Among authors: levesque m. NPJ Parkinsons Dis. 2023 Mar 27;9(1):44. doi: 10.1038/s41531-023-00484-2. NPJ Parkinsons Dis. 2023. PMID: 36973269 Free PMC article.
919 results