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Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinoma.
Bayo J, Fiore EJ, Dominguez LM, Cantero MJ, Ciarlantini MS, Malvicini M, Atorrasagasti C, Garcia MG, Rossi M, Cavasotto C, Martinez E, Comin J, Mazzolini GD. Bayo J, et al. Among authors: cavasotto c. Gut. 2021 Jul;70(7):1362-1374. doi: 10.1136/gutjnl-2020-321454. Epub 2020 Oct 26. Gut. 2021. PMID: 33106353
The ULK1-FBXW5-SEC23B nexus controls autophagy.
Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, Florens L, Washburn MP, Cavasotto CN, Fenyö D, Cuervo AM, Rossi M, Pagano M. Jeong YT, et al. Elife. 2018 Dec 31;7:e42253. doi: 10.7554/eLife.42253. Elife. 2018. PMID: 30596474 Free PMC article.
De novo design approaches targeting an envelope protein pocket to identify small molecules against dengue virus.
Leal ES, Adler NS, Fernández GA, Gebhard LG, Battini L, Aucar MG, Videla M, Monge ME, Hernández de Los Ríos A, Acosta Dávila JA, Morell ML, Cordo SM, García CC, Gamarnik AV, Cavasotto CN, Bollini M. Leal ES, et al. Among authors: cavasotto cn. Eur J Med Chem. 2019 Nov 15;182:111628. doi: 10.1016/j.ejmech.2019.111628. Epub 2019 Aug 15. Eur J Med Chem. 2019. PMID: 31472473
69 results