Lauffenburger DA - Search Results

1

Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.

Gerosa L, Chidley C, Fröhlich F, Sanchez G, Lim SK, Muhlich J, Chen JY, Vallabhaneni S, Baker GJ, Schapiro D, Atanasova MI, Chylek LA, Shi T, Yi L, Nicora CD, Claas A, Ng TSC, Kohler RH, Lauffenburger DA, Weissleder R, Miller MA, Qian WJ, Wiley HS, Sorger PK. Gerosa L, et al. Among authors: lauffenburger da. Cell Syst. 2020 Nov 18;11(5):478-494.e9. doi: 10.1016/j.cels.2020.10.002. Epub 2020 Oct 27. Cell Syst. 2020. PMID: 33113355 Free PMC article.

2

Molecular/cell engineering approach to autocrine ligand control of cell function.

Lauffenburger DA, Forsten KE, Will B, Wiley HS. Lauffenburger DA, et al. Ann Biomed Eng. 1995 May-Jun;23(3):208-15. doi: 10.1007/BF02584423. Ann Biomed Eng. 1995. PMID: 7631977 Review.

3

Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions.

French AR, Sudlow GP, Wiley HS, Lauffenburger DA. French AR, et al. Among authors: lauffenburger da. J Biol Chem. 1994 Jun 3;269(22):15749-55. J Biol Chem. 1994. PMID: 8195228 Free article.

4

Engineering epidermal growth factor for enhanced mitogenic potency.

Reddy CC, Niyogi SK, Wells A, Wiley HS, Lauffenburger DA. Reddy CC, et al. Among authors: lauffenburger da. Nat Biotechnol. 1996 Dec;14(13):1696-9. doi: 10.1038/nbt1296-1696. Nat Biotechnol. 1996. PMID: 9634854

5

Removal of the membrane-anchoring domain of epidermal growth factor leads to intracrine signaling and disruption of mammary epithelial cell organization.

Wiley HS, Woolf MF, Opresko LK, Burke PM, Will B, Morgan JR, Lauffenburger DA. Wiley HS, et al. Among authors: lauffenburger da. J Cell Biol. 1998 Nov 30;143(5):1317-28. doi: 10.1083/jcb.143.5.1317. J Cell Biol. 1998. PMID: 9832559 Free PMC article.

6

Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized.

Lauffenburger DA, Oehrtman GT, Walker L, Wiley HS. Lauffenburger DA, et al. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15368-73. doi: 10.1073/pnas.95.26.15368. Proc Natl Acad Sci U S A. 1998. PMID: 9860975 Free PMC article.

7

Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway.

Haugh JM, Schooler K, Wells A, Wiley HS, Lauffenburger DA. Haugh JM, et al. Among authors: lauffenburger da. J Biol Chem. 1999 Mar 26;274(13):8958-65. doi: 10.1074/jbc.274.13.8958. J Biol Chem. 1999. PMID: 10085141 Free article.

8

Escape of autocrine ligands into extracellular medium: experimental test of theoretical model predictions.

Oehrtman GT, Wiley HS, Lauffenburger DA. Oehrtman GT, et al. Among authors: lauffenburger da. Biotechnol Bioeng. 1998 Mar 5;57(5):571-82. Biotechnol Bioeng. 1998. PMID: 10099236

9

Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor.

Dong J, Opresko LK, Dempsey PJ, Lauffenburger DA, Coffey RJ, Wiley HS. Dong J, et al. Among authors: lauffenburger da. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6235-40. doi: 10.1073/pnas.96.11.6235. Proc Natl Acad Sci U S A. 1999. PMID: 10339571 Free PMC article.

10

Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts.

Haugh JM, Huang AC, Wiley HS, Wells A, Lauffenburger DA. Haugh JM, et al. Among authors: lauffenburger da. J Biol Chem. 1999 Nov 26;274(48):34350-60. doi: 10.1074/jbc.274.48.34350. J Biol Chem. 1999. PMID: 10567412 Free article.

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