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Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.
Tree JA, Turnbull JE, Buttigieg KR, Elmore MJ, Coombes N, Hogwood J, Mycroft-West CJ, Lima MA, Skidmore MA, Karlsson R, Chen YH, Yang Z, Spalluto CM, Staples KJ, Yates EA, Gray E, Singh D, Wilkinson T, Page CP, Carroll MW. Tree JA, et al. Among authors: chen yh. Br J Pharmacol. 2021 Feb;178(3):626-635. doi: 10.1111/bph.15304. Epub 2020 Dec 14. Br J Pharmacol. 2021. PMID: 33125711 Free PMC article.
Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain.
Schuurs ZP, Hammond E, Elli S, Rudd TR, Mycroft-West CJ, Lima MA, Skidmore MA, Karlsson R, Chen YH, Bagdonaite I, Yang Z, Ahmed YA, Richard DJ, Turnbull J, Ferro V, Coombe DR, Gandhi NS. Schuurs ZP, et al. Among authors: chen yh. Comput Struct Biotechnol J. 2021;19:2806-2818. doi: 10.1016/j.csbj.2021.05.002. Epub 2021 May 4. Comput Struct Biotechnol J. 2021. PMID: 33968333 Free PMC article.
The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models.
Davies SP, Mycroft-West CJ, Pagani I, Hill HJ, Chen YH, Karlsson R, Bagdonaite I, Guimond SE, Stamataki Z, De Lima MA, Turnbull JE, Yang Z, Vicenzi E, Skidmore MA, Khanim FL, Richardson A. Davies SP, et al. Among authors: chen yh. Front Pharmacol. 2021 Aug 6;12:660490. doi: 10.3389/fphar.2021.660490. eCollection 2021. Front Pharmacol. 2021. PMID: 34421587 Free PMC article.
Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates.
Karlsson R, Chopra P, Joshi A, Yang Z, Vakhrushev SY, Clausen TM, Painter CD, Szekeres GP, Chen YH, Sandoval DR, Hansen L, Esko JD, Pagel K, Dyer DP, Turnbull JE, Clausen H, Boons GJ, Miller RL. Karlsson R, et al. Among authors: chen yh. Sci Adv. 2021 Dec 24;7(52):eabl6026. doi: 10.1126/sciadv.abl6026. Epub 2021 Dec 22. Sci Adv. 2021. PMID: 34936441 Free PMC article.
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.
Guimond SE, Mycroft-West CJ, Gandhi NS, Tree JA, Le TT, Spalluto CM, Humbert MV, Buttigieg KR, Coombes N, Elmore MJ, Wand M, Nyström K, Said J, Setoh YX, Amarilla AA, Modhiran N, Sng JDJ, Chhabra M, Young PR, Rawle DJ, Lima MA, Yates EA, Karlsson R, Miller RL, Chen YH, Bagdonaite I, Yang Z, Stewart J, Nguyen D, Laidlaw S, Hammond E, Dredge K, Wilkinson TMA, Watterson D, Khromykh AA, Suhrbier A, Carroll MW, Trybala E, Bergström T, Ferro V, Skidmore MA, Turnbull JE. Guimond SE, et al. Among authors: chen yh. ACS Cent Sci. 2022 May 25;8(5):527-545. doi: 10.1021/acscentsci.1c01293. Epub 2022 Mar 29. ACS Cent Sci. 2022. PMID: 35647275 Free PMC article.
The GAGOme: a cell-based library of displayed glycosaminoglycans.
Chen YH, Narimatsu Y, Clausen TM, Gomes C, Karlsson R, Steentoft C, Spliid CB, Gustavsson T, Salanti A, Persson A, Malmström A, Willén D, Ellervik U, Bennett EP, Mao Y, Clausen H, Yang Z. Chen YH, et al. Nat Methods. 2018 Nov;15(11):881-888. doi: 10.1038/s41592-018-0086-z. Epub 2018 Aug 13. Nat Methods. 2018. PMID: 30104636
An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells.
Narimatsu Y, Joshi HJ, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen YH, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, Büll C, Adema GJ, Mandel U, Hansen L, Bennett EP, Varki A, Vakhrushev SY, Yang Z, Clausen H. Narimatsu Y, et al. Among authors: chen yh. Mol Cell. 2019 Jul 25;75(2):394-407.e5. doi: 10.1016/j.molcel.2019.05.017. Epub 2019 Jun 18. Mol Cell. 2019. PMID: 31227230 Free PMC article.
Genetic glycoengineering in mammalian cells.
Narimatsu Y, Büll C, Chen YH, Wandall HH, Yang Z, Clausen H. Narimatsu Y, et al. Among authors: chen yh. J Biol Chem. 2021 Jan-Jun;296:100448. doi: 10.1016/j.jbc.2021.100448. Epub 2021 Feb 20. J Biol Chem. 2021. PMID: 33617880 Free PMC article. Review.
Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection.
Bagdonaite I, Marinova IN, Rudjord-Levann AM, Pallesen EMH, King-Smith SL, Karlsson R, Rømer TB, Chen YH, Miller RL, Olofsson S, Nordén R, Bergström T, Dabelsteen S, Wandall HH. Bagdonaite I, et al. Among authors: chen yh. Nat Commun. 2023 Nov 2;14(1):7000. doi: 10.1038/s41467-023-42669-6. Nat Commun. 2023. PMID: 37919266 Free PMC article.
7,312 results