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Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.
Tree JA, Turnbull JE, Buttigieg KR, Elmore MJ, Coombes N, Hogwood J, Mycroft-West CJ, Lima MA, Skidmore MA, Karlsson R, Chen YH, Yang Z, Spalluto CM, Staples KJ, Yates EA, Gray E, Singh D, Wilkinson T, Page CP, Carroll MW. Tree JA, et al. Among authors: spalluto cm. Br J Pharmacol. 2021 Feb;178(3):626-635. doi: 10.1111/bph.15304. Epub 2020 Dec 14. Br J Pharmacol. 2021. PMID: 33125711 Free PMC article.
Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma.
Freeman A, Cellura D, Minnion M, Fernandez BO, Spalluto CM, Levett D, Bates A, Wallis T, Watson A, Jack S, Staples KJ, Grocott MPW, Feelisch M, Wilkinson TMA. Freeman A, et al. Among authors: spalluto cm. Antioxidants (Basel). 2021 Nov 30;10(12):1926. doi: 10.3390/antiox10121926. Antioxidants (Basel). 2021. PMID: 34943027 Free PMC article.
Dysregulation of COVID-19 related gene expression in the COPD lung.
Watson A, Öberg L, Angermann B, Spalluto CM, Hühn M, Burke H, Cellura D, Freeman A, Muthas D, Etal D, Belfield G, Karlsson F, Nordström K, Ostridge K, Staples KJ, Wilkinson T; MICA II Studygroup. Watson A, et al. Among authors: spalluto cm. Respir Res. 2021 May 29;22(1):164. doi: 10.1186/s12931-021-01755-3. Respir Res. 2021. PMID: 34051791 Free PMC article.
Towards an artificial human lung: modelling organ-like complexity to aid mechanistic understanding.
Humbert MV, Spalluto CM, Bell J, Blume C, Conforti F, Davies ER, Dean LSN, Elkington P, Haitchi HM, Jackson C, Jones MG, Loxham M, Lucas JS, Morgan H, Polak M, Staples KJ, Swindle EJ, Tezera L, Watson A, Wilkinson TMA. Humbert MV, et al. Among authors: spalluto cm. Eur Respir J. 2022 Dec 8;60(6):2200455. doi: 10.1183/13993003.00455-2022. Print 2022 Dec. Eur Respir J. 2022. PMID: 35777774 Free article. Review.
Inflammatory phenotyping predicts clinical outcome in COVID-19.
Burke H, Freeman A, Cellura DC, Stuart BL, Brendish NJ, Poole S, Borca F, Phan HTT, Sheard N, Williams S, Spalluto CM, Staples KJ, Clark TW, Wilkinson TMA; REACT COVID investigators. Burke H, et al. Among authors: spalluto cm. Respir Res. 2020 Sep 22;21(1):245. doi: 10.1186/s12931-020-01511-z. Respir Res. 2020. PMID: 32962703 Free PMC article.
A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection.
Blume C, Jackson CL, Spalluto CM, Legebeke J, Nazlamova L, Conforti F, Perotin JM, Frank M, Butler J, Crispin M, Coles J, Thompson J, Ridley RA, Dean LSN, Loxham M, Reikine S, Azim A, Tariq K, Johnston DA, Skipp PJ, Djukanovic R, Baralle D, McCormick CJ, Davies DE, Lucas JS, Wheway G, Mennella V. Blume C, et al. Among authors: spalluto cm. Nat Genet. 2021 Feb;53(2):205-214. doi: 10.1038/s41588-020-00759-x. Epub 2021 Jan 11. Nat Genet. 2021. PMID: 33432184
43 results