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Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.
Tree JA, Turnbull JE, Buttigieg KR, Elmore MJ, Coombes N, Hogwood J, Mycroft-West CJ, Lima MA, Skidmore MA, Karlsson R, Chen YH, Yang Z, Spalluto CM, Staples KJ, Yates EA, Gray E, Singh D, Wilkinson T, Page CP, Carroll MW. Tree JA, et al. Among authors: staples kj. Br J Pharmacol. 2021 Feb;178(3):626-635. doi: 10.1111/bph.15304. Epub 2020 Dec 14. Br J Pharmacol. 2021. PMID: 33125711 Free PMC article.
Viral infection of human lung macrophages increases PDL1 expression via IFNβ.
Staples KJ, Nicholas B, McKendry RT, Spalluto CM, Wallington JC, Bragg CW, Robinson EC, Martin K, Djukanović R, Wilkinson TM. Staples KJ, et al. PLoS One. 2015 Mar 16;10(3):e0121527. doi: 10.1371/journal.pone.0121527. eCollection 2015. PLoS One. 2015. PMID: 25775126 Free PMC article.
Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection.
Hinks TS, Wallington JC, Williams AP, Djukanović R, Staples KJ, Wilkinson TM. Hinks TS, et al. Among authors: staples kj. Am J Respir Crit Care Med. 2016 Nov 15;194(10):1208-1218. doi: 10.1164/rccm.201601-0002OC. Am J Respir Crit Care Med. 2016. PMID: 27115408 Free PMC article.
Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection.
Marriott AC, Dennis M, Kane JA, Gooch KE, Hatch G, Sharpe S, Prevosto C, Leeming G, Zekeng EG, Staples KJ, Hall G, Ryan KA, Bate S, Moyo N, Whittaker CJ, Hallis B, Silman NJ, Lalvani A, Wilkinson TM, Hiscox JA, Stewart JP, Carroll MW. Marriott AC, et al. Among authors: staples kj. PLoS One. 2016 Jun 16;11(6):e0157887. doi: 10.1371/journal.pone.0157887. eCollection 2016. PLoS One. 2016. PMID: 27311020 Free PMC article.
83 results