Lee HM - Search Results

1

A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance.

Lee HM, Kuijer MB, Ruiz Blanes N, Clark EP, Aita M, Galiano Arjona L, Kokot A, Sciaky N, Simon JM, Bhatnagar S, Philpot BD, Cerase A. Lee HM, et al. J Neurodev Disord. 2020 Nov 10;12(1):29. doi: 10.1186/s11689-020-09332-3. J Neurodev Disord. 2020. PMID: 33172406 Free PMC article.

2

Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome.

Lee HM, Clark EP, Kuijer MB, Cushman M, Pommier Y, Philpot BD. Lee HM, et al. Mol Autism. 2018 Aug 17;9:45. doi: 10.1186/s13229-018-0228-2. eCollection 2018. Mol Autism. 2018. PMID: 30140420 Free PMC article.

3

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.

Huang HS, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW Jr, Lee HM, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD. Huang HS, et al. Among authors: lee hm. Nature. 2011 Dec 21;481(7380):185-9. doi: 10.1038/nature10726. Nature. 2011. PMID: 22190039 Free PMC article.

4

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms.

Mabb AM, Simon JM, King IF, Lee HM, An LK, Philpot BD, Zylka MJ. Mabb AM, et al. Among authors: lee hm. PLoS One. 2016 May 27;11(5):e0156439. doi: 10.1371/journal.pone.0156439. eCollection 2016. PLoS One. 2016. PMID: 27231886 Free PMC article.

5

Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome.

Kim Y, Lee HM, Xiong Y, Sciaky N, Hulbert SW, Cao X, Everitt JI, Jin J, Roth BL, Jiang YH. Kim Y, et al. Among authors: lee hm. Nat Med. 2017 Feb;23(2):213-222. doi: 10.1038/nm.4257. Epub 2016 Dec 26. Nat Med. 2017. PMID: 28024084 Free PMC article.

6

A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.

Farrell MS, Pei Y, Wan Y, Yadav PN, Daigle TL, Urban DJ, Lee HM, Sciaky N, Simmons A, Nonneman RJ, Huang XP, Hufeisen SJ, Guettier JM, Moy SS, Wess J, Caron MG, Calakos N, Roth BL. Farrell MS, et al. Among authors: lee hm. Neuropsychopharmacology. 2013 Apr;38(5):854-62. doi: 10.1038/npp.2012.251. Epub 2012 Dec 5. Neuropsychopharmacology. 2013. PMID: 23303063 Free PMC article.

7

DREADDs: novel tools for drug discovery and development.

Lee HM, Giguere PM, Roth BL. Lee HM, et al. Drug Discov Today. 2014 Apr;19(4):469-73. doi: 10.1016/j.drudis.2013.10.018. Epub 2013 Nov 1. Drug Discov Today. 2014. PMID: 24184433 Free PMC article. Review.

8

Hallucinogen actions on human brain revealed.

Lee HM, Roth BL. Lee HM, et al. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1820-1. doi: 10.1073/pnas.1121358109. Epub 2012 Jan 30. Proc Natl Acad Sci U S A. 2012. PMID: 22308478 Free PMC article. No abstract available.

9

Drug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric Disorders.

Lee HM, Kim Y. Lee HM, et al. Schizophr Res Treatment. 2016;2016:6378137. doi: 10.1155/2016/6378137. Epub 2016 Mar 17. Schizophr Res Treatment. 2016. PMID: 27073698 Free PMC article. Review.

10

Quantitative analyses of how optimally heterogeneous neural codes maximize neural information in jittery transmission environments.

Roh H, Kim S, Lee HM, Im M. Roh H, et al. Among authors: lee hm. Sci Rep. 2024 Nov 28;14(1):29623. doi: 10.1038/s41598-024-81029-2. Sci Rep. 2024. PMID: 39609587 Free PMC article.

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