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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.
Baroja-Mazo A, Martín-Sánchez F, Gomez AI, Martínez CM, Amores-Iniesta J, Compan V, Barberà-Cremades M, Yagüe J, Ruiz-Ortiz E, Antón J, Buján S, Couillin I, Brough D, Arostegui JI, Pelegrín P. Baroja-Mazo A, et al. Among authors: pelegrin p. Nat Immunol. 2014 Aug;15(8):738-48. doi: 10.1038/ni.2919. Epub 2014 Jun 22. Nat Immunol. 2014. PMID: 24952504
Inflammasome-dependent IL-1β release depends upon membrane permeabilisation.
Martín-Sánchez F, Diamond C, Zeitler M, Gomez AI, Baroja-Mazo A, Bagnall J, Spiller D, White M, Daniels MJ, Mortellaro A, Peñalver M, Paszek P, Steringer JP, Nickel W, Brough D, Pelegrín P. Martín-Sánchez F, et al. Among authors: pelegrin p. Cell Death Differ. 2016 Jul;23(7):1219-31. doi: 10.1038/cdd.2015.176. Epub 2016 Feb 12. Cell Death Differ. 2016. PMID: 26868913 Free PMC article.
Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death.
Salaro E, Rambaldi A, Falzoni S, Amoroso FS, Franceschini A, Sarti AC, Bonora M, Cavazzini F, Rigolin GM, Ciccone M, Audrito V, Deaglio S, Pelegrin P, Pinton P, Cuneo A, Di Virgilio F. Salaro E, et al. Among authors: pelegrin p. Sci Rep. 2016 May 25;6:26280. doi: 10.1038/srep26280. Sci Rep. 2016. PMID: 27221966 Free PMC article.
Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation.
Lordén G, Sanjuán-García I, de Pablo N, Meana C, Alvarez-Miguel I, Pérez-García MT, Pelegrín P, Balsinde J, Balboa MA. Lordén G, et al. Among authors: pelegrin p. J Exp Med. 2017 Feb;214(2):511-528. doi: 10.1084/jem.20161452. Epub 2016 Dec 28. J Exp Med. 2017. PMID: 28031477 Free PMC article.
Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease.
Cocco M, Pellegrini C, Martínez-Banaclocha H, Giorgis M, Marini E, Costale A, Miglio G, Fornai M, Antonioli L, López-Castejón G, Tapia-Abellán A, Angosto D, Hafner-Bratkovič I, Regazzoni L, Blandizzi C, Pelegrín P, Bertinaria M. Cocco M, et al. Among authors: pelegrin p. J Med Chem. 2017 May 11;60(9):3656-3671. doi: 10.1021/acs.jmedchem.6b01624. Epub 2017 Apr 24. J Med Chem. 2017. PMID: 28410442
151 results