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Page 1
Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity.
Yamada Y, Takashima H, Walmsley DL, Ushiyama F, Matsuda Y, Kanazawa H, Yamaguchi-Sasaki T, Tanaka-Yamamoto N, Yamagishi J, Kurimoto-Tsuruta R, Ogata Y, Ohtake N, Angove H, Baker L, Harris R, Macias A, Robertson A, Surgenor A, Watanabe H, Nakano K, Mima M, Iwamoto K, Okada A, Takata I, Hitaka K, Tanaka A, Fujita K, Sugiyama H, Hubbard RE. Yamada Y, et al. Among authors: nakano k. J Med Chem. 2020 Dec 10;63(23):14805-14820. doi: 10.1021/acs.jmedchem.0c01215. Epub 2020 Nov 19. J Med Chem. 2020. PMID: 33210531
Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation.
Ushiyama F, Amada H, Takeuchi T, Tanaka-Yamamoto N, Kanazawa H, Nakano K, Mima M, Masuko A, Takata I, Hitaka K, Iwamoto K, Sugiyama H, Ohtake N. Ushiyama F, et al. Among authors: nakano k. ACS Omega. 2020 Apr 24;5(17):10145-10159. doi: 10.1021/acsomega.0c00865. eCollection 2020 May 5. ACS Omega. 2020. PMID: 32391502 Free PMC article.
Lead generation from N-[benzyl(4-phenylbutyl)carbamoyl]amino acid as a novel LPA1 antagonist for the treatment of systemic sclerosis.
Kobayashi Y, Uneuchi F, Naruse T, Matsuda D, Okumura-Kitajima L, Kajiyama H, Wada R, Yonemoto Y, Nakano K, Toki H, Kamigaso S, Yamagishi J, Tokura S, Kakinuma H, Kuroda S. Kobayashi Y, et al. Among authors: nakano k. Eur J Med Chem. 2023 Nov 15;260:115749. doi: 10.1016/j.ejmech.2023.115749. Epub 2023 Aug 20. Eur J Med Chem. 2023. PMID: 37639822
Structural design of the anti-TNFα therapeutic NANOBODY® compound, ozoralizumab, to support its potent and sustained clinical efficacy.
Mima M, Mishima-Tsumagari C, Nakano K, Morimoto M, Ogata H, Sakata M, Iwaoka R, Iwata K, Hachiuma K, Iwamoto K, Fujii Y, Kurokawa T. Mima M, et al. Among authors: nakano k. Biochem Biophys Res Commun. 2024 Nov 19;734:150454. doi: 10.1016/j.bbrc.2024.150454. Epub 2024 Jul 26. Biochem Biophys Res Commun. 2024. PMID: 39083975 Free article. No abstract available.
Relationship Between the Presence of Red Complex Species and the Distribution of Other Oral Bacteria, Including Major Periodontal Pathogens in Older Japanese Individuals.
Kametani M, Nagasawa Y, Usuda M, Kaneki A, Ogawa M, Shojima K, Yamazaki H, Tokumoto K, Matsuoka D, Suehara K, Suehiro Y, Akitomo T, Mitsuhata C, Misaki T, Ito S, Naka S, Matsumoto-Nakano M, Nakano K, Kishimoto H, Shinmura K, Nomura R. Kametani M, et al. Among authors: nakano k. Int J Mol Sci. 2024 Nov 14;25(22):12243. doi: 10.3390/ijms252212243. Int J Mol Sci. 2024. PMID: 39596308 Free PMC article.
GDF15 propeptide promotes bone metastasis of castration-resistant prostate cancer by augmenting the bone microenvironment.
Yamamichi G, Kato T, Arakawa N, Ino Y, Ujike T, Nakano K, Koh Y, Motoyama Y, Outani H, Myoba S, Ishizuya Y, Yamamoto Y, Hatano K, Kawashima A, Fukuhara S, Uemura H, Okada S, Morii E, Nonomura N, Uemura M. Yamamichi G, et al. Among authors: nakano k. Biomark Res. 2024 Nov 25;12(1):147. doi: 10.1186/s40364-024-00695-6. Biomark Res. 2024. PMID: 39587633 Free PMC article.
3,004 results