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GATA zinc finger domain-containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with β-thalassaemia through impaired formation of methyl-binding domain protein 2 (MBD2)-containing nucleosome remodelling and deacetylation (NuRD) complex.
Liang Y, Zhang X, Liu Y, Wang L, Ye Y, Tan X, Pu J, Zhang Q, Bao X, Wei X, Li D, Kurita R, Nakamura Y, Li D, Xu X. Liang Y, et al. Among authors: nakamura y. Br J Haematol. 2021 Jun;193(6):1220-1227. doi: 10.1111/bjh.17511. Epub 2021 May 17. Br J Haematol. 2021. PMID: 33997955
The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene.
Fugazza C, Barbarani G, Elangovan S, Marini MG, Giolitto S, Font-Monclus I, Marongiu MF, Manunza L, Strouboulis J, Cantù C, Gasparri F, Barabino SML, Nakamura Y, Ottolenghi S, Moi P, Ronchi AE. Fugazza C, et al. Among authors: nakamura y. Haematologica. 2021 Feb 1;106(2):474-482. doi: 10.3324/haematol.2019.241224. Haematologica. 2021. PMID: 32107331 Free PMC article.
Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL.
Trakarnsanga K, Wilson MC, Lau W, Singleton BK, Parsons SF, Sakuntanaga P, Kurita R, Nakamura Y, Anstee DJ, Frayne J. Trakarnsanga K, et al. Among authors: nakamura y. Haematologica. 2014 Nov;99(11):1677-85. doi: 10.3324/haematol.2014.110155. Epub 2014 Aug 8. Haematologica. 2014. PMID: 25107887 Free PMC article.
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