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Page 1
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.
Rodrigues TS, de Sá KSG, Ishimoto AY, Becerra A, Oliveira S, Almeida L, Gonçalves AV, Perucello DB, Andrade WA, Castro R, Veras FP, Toller-Kawahisa JE, Nascimento DC, de Lima MHF, Silva CMS, Caetite DB, Martins RB, Castro IA, Pontelli MC, de Barros FC, do Amaral NB, Giannini MC, Bonjorno LP, Lopes MIF, Santana RC, Vilar FC, Auxiliadora-Martins M, Luppino-Assad R, de Almeida SCL, de Oliveira FR, Batah SS, Siyuan L, Benatti MN, Cunha TM, Alves-Filho JC, Cunha FQ, Cunha LD, Frantz FG, Kohlsdorf T, Fabro AT, Arruda E, de Oliveira RDR, Louzada-Junior P, Zamboni DS. Rodrigues TS, et al. Among authors: benatti mn. J Exp Med. 2021 Mar 1;218(3):e20201707. doi: 10.1084/jem.20201707. J Exp Med. 2021. PMID: 33231615 Free PMC article.
SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology.
Veras FP, Pontelli MC, Silva CM, Toller-Kawahisa JE, de Lima M, Nascimento DC, Schneider AH, Caetité D, Tavares LA, Paiva IM, Rosales R, Colón D, Martins R, Castro IA, Almeida GM, Lopes MIF, Benatti MN, Bonjorno LP, Giannini MC, Luppino-Assad R, Almeida SL, Vilar F, Santana R, Bollela VR, Auxiliadora-Martins M, Borges M, Miranda CH, Pazin-Filho A, da Silva LLP, Cunha LD, Zamboni DS, Dal-Pizzol F, Leiria LO, Siyuan L, Batah S, Fabro A, Mauad T, Dolhnikoff M, Duarte-Neto A, Saldiva P, Cunha TM, Alves-Filho JC, Arruda E, Louzada-Junior P, Oliveira RD, Cunha FQ. Veras FP, et al. Among authors: benatti mn. J Exp Med. 2020 Dec 7;217(12):e20201129. doi: 10.1084/jem.20201129. J Exp Med. 2020. PMID: 32926098 Free PMC article.
Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial.
Lopes MI, Bonjorno LP, Giannini MC, Amaral NB, Menezes PI, Dib SM, Gigante SL, Benatti MN, Rezek UC, Emrich-Filho LL, Sousa BAA, Almeida SCL, Luppino Assad R, Veras FP, Schneider A, Rodrigues TS, Leiria LOS, Cunha LD, Alves-Filho JC, Cunha TM, Arruda E, Miranda CH, Pazin-Filho A, Auxiliadora-Martins M, Borges MC, Fonseca BAL, Bollela VR, Del-Ben CM, Cunha FQ, Zamboni DS, Santana RC, Vilar FC, Louzada-Junior P, Oliveira RDR. Lopes MI, et al. Among authors: benatti mn. RMD Open. 2021 Feb;7(1):e001455. doi: 10.1136/rmdopen-2020-001455. RMD Open. 2021. PMID: 33542047 Free PMC article. Clinical Trial.
Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients.
Potje SR, Costa TJ, Fraga-Silva TFC, Martins RB, Benatti MN, Almado CEL, de Sá KSG, Bonato VLD, Arruda E, Louzada-Junior P, Oliveira RDR, Zamboni DS, Becari C, Auxiliadora-Martins M, Tostes RC. Potje SR, et al. Among authors: benatti mn. Life Sci. 2021 Jul 1;276:119376. doi: 10.1016/j.lfs.2021.119376. Epub 2021 Mar 27. Life Sci. 2021. PMID: 33781826 Free PMC article.
Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage.
Costa TJ, Potje SR, Fraga-Silva TFC, da Silva-Neto JA, Barros PR, Rodrigues D, Machado MR, Martins RB, Santos-Eichler RA, Benatti MN, de Sá KSG, Almado CEL, Castro ÍA, Pontelli MC, Serra L, Carneiro FS, Becari C, Louzada-Junior P, Oliveira RDR, Zamboni DS, Arruda E, Auxiliadora-Martins M, Giachini FRC, Bonato VLD, Zachara NE, Bomfim GF, Tostes RC. Costa TJ, et al. Among authors: benatti mn. Vascul Pharmacol. 2022 Feb;142:106946. doi: 10.1016/j.vph.2021.106946. Epub 2021 Nov 25. Vascul Pharmacol. 2022. PMID: 34838735 Free PMC article.
COVID-19 bimodal clinical and pathological phenotypes.
Batah SS, Benatti MN, Siyuan L, Telini WM, Barboza JO, Menezes MB, Nadai TR, Sá KSG, Vaswani CM, Gupta S, Zamboni DS, Wada DT, Calado RT, Oliveira RDR, Louzada-Junior P, Auxiliadora-Martins M, Veras FP, Cunha LD, Cunha TM, Luppino-Assad R, Balancin ML, Morais SS, Martins RB, Arruda E, Chahud F, Santos MK, Cetlin AA, Cunha FQ, Dos Santos C, Capelozzi VL, Fukuoka J, Achcar RD, Fabro AT. Batah SS, et al. Among authors: benatti mn. Clin Transl Med. 2022 Jan;12(1):e648. doi: 10.1002/ctm2.648. Clin Transl Med. 2022. PMID: 35075808 Free PMC article. No abstract available.
SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients.
Pontelli MC, Castro ÍA, Martins RB, La Serra L, Veras FP, Nascimento DC, Silva CM, Cardoso RS, Rosales R, Gomes R, Lima TM, Souza JP, Vitti BC, Caetité DB, de Lima MHF, Stumpf SD, Thompson CE, Bloyet LM, Toller-Kawahisa JE, Giannini MC, Bonjorno LP, Lopes MIF, Batah SS, Siyuan L, Luppino-Assad R, Almeida SCL, Oliveira FR, Benatti MN, Pontes LLF, Santana RC, Vilar FC, Auxiliadora-Martins M, Shi PY, Cunha TM, Calado RT, Alves-Filho JC, Zamboni DS, Fabro AT, Louzada-Junior P, Oliveira RDR, Whelan SPJ, Cunha FQ, Arruda E. Pontelli MC, et al. Among authors: benatti mn. J Mol Cell Biol. 2022 Aug 17;14(4):mjac021. doi: 10.1093/jmcb/mjac021. J Mol Cell Biol. 2022. PMID: 35451490 Free PMC article.
Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells.
Salina ACG, Dos-Santos D, Rodrigues TS, Fortes-Rocha M, Freitas-Filho EG, Alzamora-Terrel DL, Castro IMS, Fraga da Silva TFC, de Lima MHF, Nascimento DC, Silva CM, Toller-Kawahisa JE, Becerra A, Oliveira S, Caetité DB, Almeida L, Ishimoto AY, Lima TM, Martins RB, Veras F, do Amaral NB, Giannini MC, Bonjorno LP, Lopes MIF, Benatti MN, Batah SS, Santana RC, Vilar FC, Martins MA, Assad RL, de Almeida SCL, de Oliveira FR, Arruda Neto E, Cunha TM, Alves-Filho JC, Bonato VLD, Cunha FQ, Fabro AT, Nakaya HI, Zamboni DS, Louzada-Junior P, Oliveira RDR, Cunha LD. Salina ACG, et al. Among authors: benatti mn. Elife. 2022 Jun 6;11:e74443. doi: 10.7554/eLife.74443. Elife. 2022. PMID: 35666101 Free PMC article.
17 results