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Page 1
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.
Rodrigues TS, de Sá KSG, Ishimoto AY, Becerra A, Oliveira S, Almeida L, Gonçalves AV, Perucello DB, Andrade WA, Castro R, Veras FP, Toller-Kawahisa JE, Nascimento DC, de Lima MHF, Silva CMS, Caetite DB, Martins RB, Castro IA, Pontelli MC, de Barros FC, do Amaral NB, Giannini MC, Bonjorno LP, Lopes MIF, Santana RC, Vilar FC, Auxiliadora-Martins M, Luppino-Assad R, de Almeida SCL, de Oliveira FR, Batah SS, Siyuan L, Benatti MN, Cunha TM, Alves-Filho JC, Cunha FQ, Cunha LD, Frantz FG, Kohlsdorf T, Fabro AT, Arruda E, de Oliveira RDR, Louzada-Junior P, Zamboni DS. Rodrigues TS, et al. Among authors: giannini mc. J Exp Med. 2021 Mar 1;218(3):e20201707. doi: 10.1084/jem.20201707. J Exp Med. 2021. PMID: 33231615 Free PMC article.
SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients.
Pontelli MC, Castro ÍA, Martins RB, La Serra L, Veras FP, Nascimento DC, Silva CM, Cardoso RS, Rosales R, Gomes R, Lima TM, Souza JP, Vitti BC, Caetité DB, de Lima MHF, Stumpf SD, Thompson CE, Bloyet LM, Toller-Kawahisa JE, Giannini MC, Bonjorno LP, Lopes MIF, Batah SS, Siyuan L, Luppino-Assad R, Almeida SCL, Oliveira FR, Benatti MN, Pontes LLF, Santana RC, Vilar FC, Auxiliadora-Martins M, Shi PY, Cunha TM, Calado RT, Alves-Filho JC, Zamboni DS, Fabro AT, Louzada-Junior P, Oliveira RDR, Whelan SPJ, Cunha FQ, Arruda E. Pontelli MC, et al. Among authors: giannini mc. J Mol Cell Biol. 2022 Aug 17;14(4):mjac021. doi: 10.1093/jmcb/mjac021. J Mol Cell Biol. 2022. PMID: 35451490 Free PMC article.
Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells.
Salina ACG, Dos-Santos D, Rodrigues TS, Fortes-Rocha M, Freitas-Filho EG, Alzamora-Terrel DL, Castro IMS, Fraga da Silva TFC, de Lima MHF, Nascimento DC, Silva CM, Toller-Kawahisa JE, Becerra A, Oliveira S, Caetité DB, Almeida L, Ishimoto AY, Lima TM, Martins RB, Veras F, do Amaral NB, Giannini MC, Bonjorno LP, Lopes MIF, Benatti MN, Batah SS, Santana RC, Vilar FC, Martins MA, Assad RL, de Almeida SCL, de Oliveira FR, Arruda Neto E, Cunha TM, Alves-Filho JC, Bonato VLD, Cunha FQ, Fabro AT, Nakaya HI, Zamboni DS, Louzada-Junior P, Oliveira RDR, Cunha LD. Salina ACG, et al. Among authors: giannini mc. Elife. 2022 Jun 6;11:e74443. doi: 10.7554/eLife.74443. Elife. 2022. PMID: 35666101 Free PMC article.
SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology.
Veras FP, Pontelli MC, Silva CM, Toller-Kawahisa JE, de Lima M, Nascimento DC, Schneider AH, Caetité D, Tavares LA, Paiva IM, Rosales R, Colón D, Martins R, Castro IA, Almeida GM, Lopes MIF, Benatti MN, Bonjorno LP, Giannini MC, Luppino-Assad R, Almeida SL, Vilar F, Santana R, Bollela VR, Auxiliadora-Martins M, Borges M, Miranda CH, Pazin-Filho A, da Silva LLP, Cunha LD, Zamboni DS, Dal-Pizzol F, Leiria LO, Siyuan L, Batah S, Fabro A, Mauad T, Dolhnikoff M, Duarte-Neto A, Saldiva P, Cunha TM, Alves-Filho JC, Arruda E, Louzada-Junior P, Oliveira RD, Cunha FQ. Veras FP, et al. Among authors: giannini mc. J Exp Med. 2020 Dec 7;217(12):e20201129. doi: 10.1084/jem.20201129. J Exp Med. 2020. PMID: 32926098 Free PMC article.
Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology.
Silva CMS, Wanderley CWS, Veras FP, Gonçalves AV, Lima MHF, Toller-Kawahisa JE, Gomes GF, Nascimento DC, Monteiro VVS, Paiva IM, Almeida CJLR, Caetité DB, Silva JC, Lopes MIF, Bonjorno LP, Giannini MC, Amaral NB, Benatti MN, Santana RC, Damasceno LEA, Silva BMS, Schneider AH, Castro IMS, Silva JCS, Vasconcelos AP, Gonçalves TT, Batah SS, Rodrigues TS, Costa VF, Pontelli MC, Martins RB, Martins TV, Espósito DLA, Cebinelli GCM, da Fonseca BAL, Leiria LOS, Cunha LD, Arruda E, Nakaia HI, Fabro AT, Oliveira RDR, Zamboni DS, Louzada-Junior P, Cunha TM, Alves-Filho JCF, Cunha FQ. Silva CMS, et al. Among authors: giannini mc. Crit Care. 2022 Jul 7;26(1):206. doi: 10.1186/s13054-022-04062-5. Crit Care. 2022. PMID: 35799268 Free PMC article.
Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial.
Lopes MI, Bonjorno LP, Giannini MC, Amaral NB, Menezes PI, Dib SM, Gigante SL, Benatti MN, Rezek UC, Emrich-Filho LL, Sousa BAA, Almeida SCL, Luppino Assad R, Veras FP, Schneider A, Rodrigues TS, Leiria LOS, Cunha LD, Alves-Filho JC, Cunha TM, Arruda E, Miranda CH, Pazin-Filho A, Auxiliadora-Martins M, Borges MC, Fonseca BAL, Bollela VR, Del-Ben CM, Cunha FQ, Zamboni DS, Santana RC, Vilar FC, Louzada-Junior P, Oliveira RDR. Lopes MI, et al. Among authors: giannini mc. RMD Open. 2021 Feb;7(1):e001455. doi: 10.1136/rmdopen-2020-001455. RMD Open. 2021. PMID: 33542047 Free PMC article. Clinical Trial.
Colchicine reduces the activation of NLRP3 inflammasome in COVID-19 patients.
Amaral NB, Rodrigues TS, Giannini MC, Lopes MI, Bonjorno LP, Menezes PISO, Dib SM, Gigante SLG, Benatti MN, Rezek UC, Emrich-Filho LL, Sousa BA, Almeida SCL, Luppino-Assad R, Veras FP, Schneider AH, Leiria LOS, Cunha LD, Alves-Filho JC, Cunha TM, Arruda E, Miranda CH, Pazin-Filho A, Auxiliadora-Martins M, Borges MC, Fonseca BAL, Bollela VR, Del-Ben CM, Cunha FQ, Santana RC, Vilar FC, Zamboni DS, Louzada-Junior P, Oliveira RDR. Amaral NB, et al. Among authors: giannini mc. Inflamm Res. 2023 May;72(5):895-899. doi: 10.1007/s00011-023-01718-y. Epub 2023 Mar 14. Inflamm Res. 2023. PMID: 36917217 Free PMC article. Clinical Trial.
Infection of human lymphomononuclear cells by SARS-CoV-2.
Pontelli MC, Castro IA, Martins RB, Veras FP, Serra L, Nascimento DC, Cardoso RS, Rosales R, Lima TM, Souza JP, Caetité DB, de Lima MHF, Kawahisa JT, Giannini MC, Bonjorno LP, Lopes MIF, Batah SS, Siyuan L, Assad RL, Almeida SCL, Oliveira FR, Benatti MN, Pontes LLF, Santana RC, Vilar FC, Martins MA, Cunha TM, Calado RT, Alves-Filho JC, Zamboni DS, Fabro A, Louzada-Junior P, Oliveira RDR, Cunha FQ, Arruda E. Pontelli MC, et al. Among authors: giannini mc. bioRxiv [Preprint]. 2020 Aug 7:2020.07.28.225912. doi: 10.1101/2020.07.28.225912. bioRxiv. 2020. Update in: J Mol Cell Biol. 2022 Aug 17;14(4):mjac021. doi: 10.1093/jmcb/mjac021 PMID: 34013264 Free PMC article. Updated. Preprint.
26 results