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Mechanism of Thimerosal-Induced Structural Destabilization of a Recombinant Rotavirus P[4] Protein Antigen Formulated as a Multi-Dose Vaccine.
Kaur K, Xiong J, Sawant N, Agarwal S, Hickey JM, Holland DA, Mukhopadhyay TK, Brady JR, Dalvie NC, Tracey MK, Love KR, Love JC, Weis DD, Joshi SB, Volkin DB. Kaur K, et al. Among authors: brady jr. J Pharm Sci. 2021 Mar;110(3):1054-1066. doi: 10.1016/j.xphs.2020.11.033. Epub 2020 Dec 3. J Pharm Sci. 2021. PMID: 33278412 Free PMC article.
On-demand manufacturing of clinical-quality biopharmaceuticals.
Crowell LE, Lu AE, Love KR, Stockdale A, Timmick SM, Wu D, Wang YA, Doherty W, Bonnyman A, Vecchiarello N, Goodwine C, Bradbury L, Brady JR, Clark JJ, Colant NA, Cvetkovic A, Dalvie NC, Liu D, Liu Y, Mascarenhas CA, Matthews CB, Mozdzierz NJ, Shah KA, Wu SL, Hancock WS, Braatz RD, Cramer SM, Love JC. Crowell LE, et al. Among authors: brady jr. Nat Biotechnol. 2018 Oct 1:10.1038/nbt.4262. doi: 10.1038/nbt.4262. Online ahead of print. Nat Biotechnol. 2018. PMID: 30272677 Free PMC article.
Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens.
Sawant N, Kaur K, Holland DA, Hickey JM, Agarwal S, Brady JR, Dalvie NC, Tracey MK, Velez-Suberbie ML, Morris SA, Jacob SI, Bracewell DG, Mukhopadhyay TK, Love KR, Love JC, Joshi SB, Volkin DB. Sawant N, et al. Among authors: brady jr. J Pharm Sci. 2021 Mar;110(3):1042-1053. doi: 10.1016/j.xphs.2020.11.039. Epub 2020 Dec 5. J Pharm Sci. 2021. PMID: 33285182 Free PMC article.
Modeling of copy number variability in Pichia pastoris.
Lu AE, Maloney AJ, Dalvie NC, Brady JR, Love KR, Love JC, Braatz RD. Lu AE, et al. Among authors: brady jr. Biotechnol Bioeng. 2021 May;118(5):1832-1839. doi: 10.1002/bit.27698. Epub 2021 Feb 19. Biotechnol Bioeng. 2021. PMID: 33527350
Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters.
Dalvie NC, Rodriguez-Aponte SA, Hartwell BL, Tostanoski LH, Biedermann AM, Crowell LE, Kaur K, Kumru O, Carter L, Yu J, Chang A, McMahan K, Courant T, Lebas C, Lemnios AA, Rodrigues KA, Silva M, Johnston RS, Naranjo CA, Tracey MK, Brady JR, Whittaker CA, Yun D, Kar S, Porto M, Lok M, Andersen H, Lewis MG, Love KR, Camp DL, Silverman JM, Kleanthous H, Joshi SB, Volkin DB, Dubois PM, Collin N, King NP, Barouch DH, Irvine DJ, Love JC. Dalvie NC, et al. Among authors: brady jr. bioRxiv [Preprint]. 2021 Mar 4:2021.03.03.433558. doi: 10.1101/2021.03.03.433558. bioRxiv. 2021. Update in: Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2106845118. doi: 10.1073/pnas.2106845118 PMID: 33688647 Free PMC article. Updated. Preprint.
Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus.
Dalvie NC, Brady JR, Crowell LE, Tracey MK, Biedermann AM, Kaur K, Hickey JM, Kristensen DL 2nd, Bonnyman AD, Rodriguez-Aponte SA, Whittaker CA, Bok M, Vega C, Mukhopadhyay TK, Joshi SB, Volkin DB, Parreño V, Love KR, Love JC. Dalvie NC, et al. Among authors: brady jr. Microb Cell Fact. 2021 May 1;20(1):94. doi: 10.1186/s12934-021-01583-6. Microb Cell Fact. 2021. PMID: 33933073 Free PMC article.
95 results