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Page 1
Small-molecule inhibitors of human mitochondrial DNA transcription.
Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG. Bonekamp NA, et al. Among authors: felser a. Nature. 2020 Dec;588(7839):712-716. doi: 10.1038/s41586-020-03048-z. Epub 2020 Dec 16. Nature. 2020. PMID: 33328633
Rescue of primary ubiquinone deficiency due to a novel COQ7 defect using 2,4-dihydroxybensoic acid.
Freyer C, Stranneheim H, Naess K, Mourier A, Felser A, Maffezzini C, Lesko N, Bruhn H, Engvall M, Wibom R, Barbaro M, Hinze Y, Magnusson M, Andeer R, Zetterström RH, von Döbeln U, Wredenberg A, Wedell A. Freyer C, et al. Among authors: felser a. J Med Genet. 2015 Nov;52(11):779-83. doi: 10.1136/jmedgenet-2015-102986. Epub 2015 Jun 17. J Med Genet. 2015. PMID: 26084283 Free PMC article.
PPAR-γ regulates the effector function of human T helper 9 cells by promoting glycolysis.
Bertschi NL, Steck O, Luther F, Bazzini C, von Meyenn L, Schärli S, Vallone A, Felser A, Keller I, Friedli O, Freigang S, Begré N, Radonjic-Hoesli S, Lamos C, Gabutti MP, Benzaquen M, Laimer M, Simon D, Nuoffer JM, Schlapbach C. Bertschi NL, et al. Among authors: felser a. Nat Commun. 2023 Apr 29;14(1):2471. doi: 10.1038/s41467-023-38233-x. Nat Commun. 2023. PMID: 37120582 Free PMC article.
The histidine triad nucleotide-binding protein 2 (HINT-2) positively regulates hepatocellular energy metabolism.
Rajasekaran R, Felser A, Nuoffer JM, Dufour JF, St-Pierre MV. Rajasekaran R, et al. Among authors: felser a. FASEB J. 2018 Sep;32(9):5143-5161. doi: 10.1096/fj.201701429R. Epub 2018 Apr 18. FASEB J. 2018. PMID: 29913563
We postulated that the absence of HINT-2 induces a defect in mitochondria bioenergetics. Isolated Hint2(-/-) hepatocytes produced less ATP and generated a lower mitochondrial membrane potential than did Hint2(+/+) hepatocytes. ...The bioenergetics deficit accumulate …
We postulated that the absence of HINT-2 induces a defect in mitochondria bioenergetics. Isolated Hint2(-/-) hepatocytes produced les …
28 results