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Small-molecule inhibitors of human mitochondrial DNA transcription.
Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG. Bonekamp NA, et al. Among authors: hillen hs. Nature. 2020 Dec;588(7839):712-716. doi: 10.1038/s41586-020-03048-z. Epub 2020 Dec 16. Nature. 2020. PMID: 33328633
Mechanism of Transcription Anti-termination in Human Mitochondria.
Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D. Hillen HS, et al. Cell. 2017 Nov 16;171(5):1082-1093.e13. doi: 10.1016/j.cell.2017.09.035. Epub 2017 Oct 12. Cell. 2017. PMID: 29033127 Free PMC article.
Structural basis of mitochondrial transcription.
Hillen HS, Temiakov D, Cramer P. Hillen HS, et al. Nat Struct Mol Biol. 2018 Sep;25(9):754-765. doi: 10.1038/s41594-018-0122-9. Epub 2018 Sep 6. Nat Struct Mol Biol. 2018. PMID: 30190598 Free PMC article. Review.
Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes.
Grimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, Hüttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Böttcher B, Szalay AA, Cramer P, Fischer U. Grimm C, et al. Among authors: hillen hs. Cell. 2019 Dec 12;179(7):1537-1550.e19. doi: 10.1016/j.cell.2019.11.024. Cell. 2019. PMID: 31835032 Free article.
Structure of replicating SARS-CoV-2 polymerase.
Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P. Hillen HS, et al. Nature. 2020 Aug;584(7819):154-156. doi: 10.1038/s41586-020-2368-8. Epub 2020 May 21. Nature. 2020. PMID: 32438371
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.
Kokic G, Hillen HS, Tegunov D, Dienemann C, Seitz F, Schmitzova J, Farnung L, Siewert A, Höbartner C, Cramer P. Kokic G, et al. Among authors: hillen hs. Nat Commun. 2021 Jan 12;12(1):279. doi: 10.1038/s41467-020-20542-0. Nat Commun. 2021. PMID: 33436624 Free PMC article.
Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir.
Cramer P, Kokic G, Dienemann C, Höbartner C, Hillen HS. Cramer P, et al. Among authors: hillen hs. Biospektrum (Heidelb). 2021;27(1):49-53. doi: 10.1007/s12268-021-1516-6. Epub 2021 Feb 12. Biospektrum (Heidelb). 2021. PMID: 33612990 Free PMC article. Review. German.
31 results