Downer EJ - Search Results

1

Phytocannabinoid-dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity.

Damstra-Oddy JL, Warren EC, Perry CJ, Desfougères Y, Fitzpatrick JK, Schaf J, Costelloe L, Hind W, Downer EJ, Saiardi A, Williams RSB. Damstra-Oddy JL, et al. Among authors: downer ej. Br J Pharmacol. 2021 Mar;178(5):1149-1163. doi: 10.1111/bph.15351. Epub 2021 Jan 18. Br J Pharmacol. 2021. PMID: 33347604 Free PMC article.

2

Tetrahydrocannabinol-induced neurotoxicity depends on CB1 receptor-mediated c-Jun N-terminal kinase activation in cultured cortical neurons.

Downer EJ, Fogarty MP, Campbell VA. Downer EJ, et al. Br J Pharmacol. 2003 Oct;140(3):547-57. doi: 10.1038/sj.bjp.0705464. Br J Pharmacol. 2003. PMID: 14522843 Free PMC article.

3

The role of cannabinoids in adult neurogenesis.

Prenderville JA, Kelly ÁM, Downer EJ. Prenderville JA, et al. Among authors: downer ej. Br J Pharmacol. 2015 Aug;172(16):3950-63. doi: 10.1111/bph.13186. Epub 2015 Jun 16. Br J Pharmacol. 2015. PMID: 25951750 Free PMC article. Review.

4

Toll-like receptor signalling as a cannabinoid target in Multiple Sclerosis.

Fitzpatrick JK, Downer EJ. Fitzpatrick JK, et al. Among authors: downer ej. Neuropharmacology. 2017 Feb;113(Pt B):618-626. doi: 10.1016/j.neuropharm.2016.04.009. Epub 2016 Apr 11. Neuropharmacology. 2017. PMID: 27079840 Review.

5

MyD88-dependent and -independent signalling via TLR3 and TLR4 are differentially modulated by Δ⁹-tetrahydrocannabinol and cannabidiol in human macrophages.

Fitzpatrick JM, Minogue E, Curham L, Tyrrell H, Gavigan P, Hind W, Downer EJ. Fitzpatrick JM, et al. Among authors: downer ej. J Neuroimmunol. 2020 Jun 15;343:577217. doi: 10.1016/j.jneuroim.2020.577217. Epub 2020 Mar 20. J Neuroimmunol. 2020. PMID: 32244040

6

Botanically-Derived Δ⁹-Tetrahydrocannabinol and Cannabidiol, and Their 1:1 Combination, Modulate Toll-like Receptor 3 and 4 Signalling in Immune Cells from People with Multiple Sclerosis.

Fitzpatrick JM, Hackett B, Costelloe L, Hind W, Downer EJ. Fitzpatrick JM, et al. Among authors: downer ej. Molecules. 2022 Mar 8;27(6):1763. doi: 10.3390/molecules27061763. Molecules. 2022. PMID: 35335126 Free PMC article.

7

Cannflavin A inhibits TLR4-induced chemokine and cytokine expression in human macrophages.

Fitzpatrick JK, O'Riordan D, Downer EJ. Fitzpatrick JK, et al. Among authors: downer ej. Nat Prod Res. 2024 May 23:1-7. doi: 10.1080/14786419.2024.2358382. Online ahead of print. Nat Prod Res. 2024. PMID: 38780010

8

The tumour suppressor protein, p53, is involved in the activation of the apoptotic cascade by Delta9-tetrahydrocannabinol in cultured cortical neurons.

Downer EJ, Gowran A, Murphy AC, Campbell VA. Downer EJ, et al. Eur J Pharmacol. 2007 Jun 14;564(1-3):57-65. doi: 10.1016/j.ejphar.2007.02.025. Epub 2007 Feb 22. Eur J Pharmacol. 2007. PMID: 17379209

9

Cannabinoids: clearing the smoke on pain, inflammation and neurodegeneration.

Downer EJ, Finn DP. Downer EJ, et al. Br J Pharmacol. 2014 Mar;171(6):1341-4. doi: 10.1111/bph.12642. Br J Pharmacol. 2014. PMID: 24588559 Free PMC article.

10

Toll-like receptor signalling as a cannabinoid target.

Cui Sun M, Otálora-Alcaraz A, Prenderville JA, Downer EJ. Cui Sun M, et al. Among authors: downer ej. Biochem Pharmacol. 2024 Apr;222:116082. doi: 10.1016/j.bcp.2024.116082. Epub 2024 Mar 2. Biochem Pharmacol. 2024. PMID: 38438052 Free article. Review.

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