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Page 1
NAD+ metabolism and its roles in cellular processes during ageing.
Covarrubias AJ, Perrone R, Grozio A, Verdin E. Covarrubias AJ, et al. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141. doi: 10.1038/s41580-020-00313-x. Epub 2020 Dec 22. Nat Rev Mol Cell Biol. 2021. PMID: 33353981 Free PMC article. Review.
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Covarrubias AJ, et al. Nat Metab. 2020 Nov;2(11):1265-1283. doi: 10.1038/s42255-020-00305-3. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199924 Free PMC article.
Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Covarrubias AJ, et al. Nat Metab. 2021 Jan;3(1):120-121. doi: 10.1038/s42255-020-00328-w. Nat Metab. 2021. PMID: 33303985 No abstract available.
SARS-CoV-2, COVID-19 and the Ageing Immune System.
Bartleson JM, Radenkovic D, Covarrubias AJ, Furman D, Winer DA, Verdin E. Bartleson JM, et al. Among authors: covarrubias aj. Nat Aging. 2021 Sep;1(9):769-782. doi: 10.1038/s43587-021-00114-7. Epub 2021 Sep 14. Nat Aging. 2021. PMID: 34746804 Free PMC article.
Nuclear morphology is a deep learning biomarker of cellular senescence.
Heckenbach I, Mkrtchyan GV, Ezra MB, Bakula D, Madsen JS, Nielsen MH, Oró D, Osborne B, Covarrubias AJ, Idda ML, Gorospe M, Mortensen L, Verdin E, Westendorp R, Scheibye-Knudsen M. Heckenbach I, et al. Among authors: covarrubias aj. Nat Aging. 2022 Aug;2(8):742-755. doi: 10.1038/s43587-022-00263-3. Epub 2022 Aug 15. Nat Aging. 2022. PMID: 37118134 Free PMC article.
The TSC-mTOR pathway regulates macrophage polarization.
Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T. Byles V, et al. Among authors: covarrubias aj. Nat Commun. 2013;4:2834. doi: 10.1038/ncomms3834. Nat Commun. 2013. PMID: 24280772 Free PMC article.
IL-6 strikes a balance in metabolic inflammation.
Covarrubias AJ, Horng T. Covarrubias AJ, et al. Cell Metab. 2014 Jun 3;19(6):898-9. doi: 10.1016/j.cmet.2014.05.009. Cell Metab. 2014. PMID: 24896536 Free PMC article.
15 results