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Accompanying Hemoglobin Polymerization in Red Blood Cells in Patients with Sickle Cell Disease Using Fluorescence Lifetime Imaging.
Borges da Silva FA, Florindo JB, Mattos AC, Costa FF, Lorand-Metze I, Metze K. Borges da Silva FA, et al. Int J Mol Sci. 2024 Nov 15;25(22):12290. doi: 10.3390/ijms252212290. Int J Mol Sci. 2024. PMID: 39596357 Free PMC article.
These areas were interpreted as equivalent to polymerized hemoglobin. The rounded, non-sickled RBCs of SCD patients with homogeneous cytoplasm were not different from those of the erythrocytes of control patients in light microscopy. ...We believe that our study shows that …
These areas were interpreted as equivalent to polymerized hemoglobin. The rounded, non-sickled RBCs of SCD patients with homogeneous …
Genetic Modifiers of Hemoglobin Expression from a Clinical Perspective in Hemoglobinopathy Patients with Beta Thalassemia and Sickle Cell Disease.
Diamantidis MD, Ikonomou G, Argyrakouli I, Pantelidou D, Delicou S; International Hemoglobinopathy Research Network (INHERENT). Diamantidis MD, et al. Int J Mol Sci. 2024 Nov 5;25(22):11886. doi: 10.3390/ijms252211886. Int J Mol Sci. 2024. PMID: 39595957 Free PMC article. Review.
Hemoglobinopathies, namely beta-thalassemia and sickle cell disease (SCD), are hereditary diseases, characterized by molecular genetic aberrations in the beta chains of hemoglobin. These defects affect the normal production of hemoglobin with severe anemia du …
Hemoglobinopathies, namely beta-thalassemia and sickle cell disease (SCD), are hereditary diseases, characterized by molecular geneti …
Sonographic Assessment of Splenic Manifestations in Sickle Cell Disease Patients and Its Relation to Hematological Parameters: A Cross-Sectional Study in Basra, Iraq.
Sadeq HS, Abdulkareem AS, Dawood QM, Khalaf AA. Sadeq HS, et al. Cureus. 2024 Oct 24;16(10):e72322. doi: 10.7759/cureus.72322. eCollection 2024 Oct. Cureus. 2024. PMID: 39583457 Free PMC article.
Background Hemoglobinopathies, such as sickle cell disease (SCD), are inherited disorders of hemoglobin (Hb) synthesis. SCD presents with complex clinical manifestations, including anemia, painful episodes, and organ damage due to recurrent vaso-occlusion. ...Exclus …
Background Hemoglobinopathies, such as sickle cell disease (SCD), are inherited disorders of hemoglobin (Hb) synthesis. SCD pr …
Adding hydroxyurea to chronic transfusion therapy for sickle cell anemia reduces transfusion burden.
Nickel RS, Margulies S, Panchapakesan K, Chorvinsky E, Nino G, Gierdalski M, Bost J, Luban NLC, Webb J. Nickel RS, et al. Transfusion. 2024 Nov 24. doi: 10.1111/trf.18073. Online ahead of print. Transfusion. 2024. PMID: 39580793
With the addition of hydroxyurea participants had a significant increase in pretransfusion Hb S% but this was balanced by an increased Hb F% and decreased lactate dehydrogenase. One participant developed a pretransfusion Hb >11 g/dL and Hb S > 45 …
With the addition of hydroxyurea participants had a significant increase in pretransfusion Hb S% but this was balanced by an i …
Late diagnosis of sickle cell disease in adults still a challenge in developing countries: a case report.
Mswelo VE, Mubaraka K, Mohamed Y, Kyaligonza P, Xwatsal EJ. Mswelo VE, et al. J Med Case Rep. 2024 Nov 21;18(1):556. doi: 10.1186/s13256-024-04858-9. J Med Case Rep. 2024. PMID: 39568090 Free PMC article.
BACKGROUND: Sickle cell disease is a genetic disease with multisystem involvement. More than 300,000 children are born with sickle cell disease globally, with the majority of cases being in Sub-Saharan Africa. ...Physical examination revealed conjunctival pallor, ic …
BACKGROUND: Sickle cell disease is a genetic disease with multisystem involvement. More than 300,000 children are born with sickle …
Effect of voxelotor on cerebral perfusion and cerebral oxygen metabolism and cardiac stress in adult patients with sickle cell disease.
Konté K, Afzali-Hashemi L, Baas KPA, Schrantee A, Wood JC, Nur E, Nederveen AJ, Biemond BJ. Konté K, et al. Am J Hematol. 2024 Nov 20. doi: 10.1002/ajh.27522. Online ahead of print. Am J Hematol. 2024. PMID: 39564863
Sickle cell disease (SCD) is complicated by silent cerebral infarcts (SCIs), for which anemia is an important risk factor. ...Voxelotor inhibits polymerization by increasing the hemoglobin oxygen binding, ameliorating hemolytic anemia. Furthermore, anemia is related …
Sickle cell disease (SCD) is complicated by silent cerebral infarcts (SCIs), for which anemia is an important risk factor. ...Voxelot …
FT-4202, a selective pyruvate kinase R activator for sickle cell disease.
Ericsson A, Richard DJ, Wilker E, Lancia JDR, Fessler S, Troccolo P, Zheng X, Toms A, Dinsmore C, Yao L, Kuypers FA, Larkin S, Marcotte D, Fulzele K, Ribadeneira M, Guichard SM, Marshall G. Ericsson A, et al. Exp Hematol. 2024 Nov 14:104673. doi: 10.1016/j.exphem.2024.104673. Online ahead of print. Exp Hematol. 2024. PMID: 39549740 Free article.
Anemia in patients with sickle cell disease (SCD) increases 2,3-diphosphoglycerate (2,3-DPG), decreasing hemoglobin-oxygen (Hb-O(2)) affinity to improve oxygen offloading and promote hemoglobin polymerization (sickling) of red blood cells (RBCs). ...
Anemia in patients with sickle cell disease (SCD) increases 2,3-diphosphoglycerate (2,3-DPG), decreasing hemoglobin-oxygen (Hb …
Exploring Novel Strategies to Alleviate Symptoms of β-Globinopathies: Examining the Potential Role of Embryonic ε-globin Induction.
Liu J, Park K, Shen Z, Ye Y, Lee E, Herman RA, Zhu X, Lu W, Nuhfer J, Bassal MA, Tenen DG, Brunker P, Xu X, Chai L. Liu J, et al. Transfus Med Rev. 2024 Oct 18;38(4):150861. doi: 10.1016/j.tmrv.2024.150861. Online ahead of print. Transfus Med Rev. 2024. PMID: 39549502 Free article.
beta-thalassemia and sickle cell disease are among the most prevalent genetic blood disorders globally. These conditions arise from mutations in the beta-globin gene, leading to defective hemoglobin production and resulting in anemia. ...This review critically exami …
beta-thalassemia and sickle cell disease are among the most prevalent genetic blood disorders globally. These conditions arise from m …
Prevalence and predictors of Sickle Cell Nephropathy A single-center experience.
Elzorkany K, Alsalman M, AlSahlawi M, Alhedhod A, Almulhim NA, Alsultan NJ, Al-Ali EM, Ali E, Omer NE. Elzorkany K, et al. Sci Rep. 2024 Nov 15;14(1):28215. doi: 10.1038/s41598-024-79345-8. Sci Rep. 2024. PMID: 39548197 Free PMC article.
Sickle cell disease (SCD) is the most common monogenic disorder in Saudi Arabia, which associates with an increased risk of organs damage, including the kidney. ...The multivariate analysis showed that age (P = 0.001; OR 1.035; 95% CI 1.014-1.056) and low hemoglobin …
Sickle cell disease (SCD) is the most common monogenic disorder in Saudi Arabia, which associates with an increased risk of organs da …
DEPRESSION AS A PREDICTOR OF OPIOID USE DISORDER IN SICKLE CELL DISEASE PATIENTS.
Umar MU, Yakubu AI, Bakare AT, Abubakar SB, Abubakar A, Bello A, Abdullahi UU, Abdurrahman Z, Mohammad AD, Sanusi AY, Ladan A, Abubakar HB, Umar BB, Junaidu S, Ibrahim AH. Umar MU, et al. West Afr J Med. 2024 Nov 10;41(11 Suppl 1):S54-S55. West Afr J Med. 2024. PMID: 39545309
BACKGROUND: Sickle cell disease (SCD) is highly prevalent in Africa, especially in Nigeria, the most populous country, and is associated with a high mortality rate. ...AIM: To determine whether major depressive disorder is a predictor of opioid use disorder among patients …
BACKGROUND: Sickle cell disease (SCD) is highly prevalent in Africa, especially in Nigeria, the most populous country, and is associa …
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