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ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels.
Narahari AK, Kreutzberger AJ, Gaete PS, Chiu YH, Leonhardt SA, Medina CB, Jin X, Oleniacz PW, Kiessling V, Barrett PQ, Ravichandran KS, Yeager M, Contreras JE, Tamm LK, Bayliss DA. Narahari AK, et al. Among authors: medina cb. Elife. 2021 Jan 7;10:e64787. doi: 10.7554/eLife.64787. Elife. 2021. PMID: 33410749 Free PMC article.
A quantized mechanism for activation of pannexin channels.
Chiu YH, Jin X, Medina CB, Leonhardt SA, Kiessling V, Bennett BC, Shu S, Tamm LK, Yeager M, Ravichandran KS, Bayliss DA. Chiu YH, et al. Among authors: medina cb. Nat Commun. 2017 Jan 30;8:14324. doi: 10.1038/ncomms14324. Nat Commun. 2017. PMID: 28134257 Free PMC article.
Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone.
Good ME, Chiu YH, Poon IKH, Medina CB, Butcher JT, Mendu SK, DeLalio LJ, Lohman AW, Leitinger N, Barrett E, Lorenz UM, Desai BN, Jaffe IZ, Bayliss DA, Isakson BE, Ravichandran KS. Good ME, et al. Among authors: medina cb. Circ Res. 2018 Feb 16;122(4):606-615. doi: 10.1161/CIRCRESAHA.117.312380. Epub 2017 Dec 13. Circ Res. 2018. PMID: 29237722 Free PMC article.
Epithelial and Endothelial Pannexin1 Channels Mediate AKI.
Jankowski J, Perry HM, Medina CB, Huang L, Yao J, Bajwa A, Lorenz UM, Rosin DL, Ravichandran KS, Isakson BE, Okusa MD. Jankowski J, et al. Among authors: medina cb. J Am Soc Nephrol. 2018 Jul;29(7):1887-1899. doi: 10.1681/ASN.2017121306. Epub 2018 Jun 4. J Am Soc Nephrol. 2018. PMID: 29866797 Free PMC article.
Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.
Morioka S, Perry JSA, Raymond MH, Medina CB, Zhu Y, Zhao L, Serbulea V, Onengut-Gumuscu S, Leitinger N, Kucenas S, Rathmell JC, Makowski L, Ravichandran KS. Morioka S, et al. Among authors: medina cb. Nature. 2018 Nov;563(7733):714-718. doi: 10.1038/s41586-018-0735-5. Epub 2018 Nov 21. Nature. 2018. PMID: 30464343 Free PMC article.
Metabolites released from apoptotic cells act as tissue messengers.
Medina CB, Mehrotra P, Arandjelovic S, Perry JSA, Guo Y, Morioka S, Barron B, Walk SF, Ghesquière B, Krupnick AS, Lorenz U, Ravichandran KS. Medina CB, et al. Nature. 2020 Apr;580(7801):130-135. doi: 10.1038/s41586-020-2121-3. Epub 2020 Mar 18. Nature. 2020. PMID: 32238926 Free PMC article.
Deacetylation as a receptor-regulated direct activation switch for pannexin channels.
Chiu YH, Medina CB, Doyle CA, Zhou M, Narahari AK, Sandilos JK, Gonye EC, Gao HY, Guo SY, Parlak M, Lorenz UM, Conrads TP, Desai BN, Ravichandran KS, Bayliss DA. Chiu YH, et al. Among authors: medina cb. Nat Commun. 2021 Jul 23;12(1):4482. doi: 10.1038/s41467-021-24825-y. Nat Commun. 2021. PMID: 34301959 Free PMC article.
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