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The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L).
Roberts JZ, Holohan C, Sessler T, Fox J, Crawford N, Riley JS, Khawaja H, Majkut J, Evergren E, Humphreys LM, Ferris J, Higgins C, Espona-Fiedler M, Moynagh P, McDade SS, Longley DB. Roberts JZ, et al. Among authors: humphreys lm. Cell Death Differ. 2020 Sep;27(9):2726-2741. doi: 10.1038/s41418-020-0539-7. Epub 2020 Apr 20. Cell Death Differ. 2020. PMID: 32313199 Free PMC article.
FLIP as a therapeutic target in cancer.
Humphreys L, Espona-Fiedler M, Longley DB. Humphreys L, et al. FEBS J. 2018 Nov;285(22):4104-4123. doi: 10.1111/febs.14523. Epub 2018 Jun 27. FEBS J. 2018. PMID: 29806737 Free article. Review.
FLIP: A Targetable Mediator of Resistance to Radiation in Non-Small Cell Lung Cancer.
McLaughlin KA, Nemeth Z, Bradley CA, Humphreys L, Stasik I, Fenning C, Majkut J, Higgins C, Crawford N, Holohan C, Johnston PG, Harrison T, Hanna GG, Butterworth KT, Prise KM, Longley DB. McLaughlin KA, et al. Mol Cancer Ther. 2016 Oct;15(10):2432-2441. doi: 10.1158/1535-7163.MCT-16-0211. Epub 2016 Jul 29. Mol Cancer Ther. 2016. PMID: 27474150