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A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected].
Cross SH, Macalinao DG, McKie L, Rose L, Kearney AL, Rainger J, Thaung C, Keighren M, Jadeja S, West K, Kneeland SC, Smith RS, Howell GR, Young F, Robertson M, van T' Hof R, John SW, Jackson IJ. Cross SH, et al. Among authors: kearney al. PLoS Genet. 2014 May 8;10(5):e1004359. doi: 10.1371/journal.pgen.1004359. eCollection 2014 May. PLoS Genet. 2014. PMID: 24809698 Free PMC article.
Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice.
Nair KS, Hmani-Aifa M, Ali Z, Kearney AL, Ben Salem S, Macalinao DG, Cosma IM, Bouassida W, Hakim B, Benzina Z, Soto I, Söderkvist P, Howell GR, Smith RS, Ayadi H, John SW. Nair KS, et al. Among authors: kearney al. Nat Genet. 2011 Jun;43(6):579-84. doi: 10.1038/ng.813. Epub 2011 May 1. Nat Genet. 2011. PMID: 21532570 Free PMC article.
A New Wave of PI3Kα Inhibitors.
Kearney AL, Vasan N. Kearney AL, et al. Cancer Discov. 2023 Nov 1;13(11):2313-2315. doi: 10.1158/2159-8290.CD-23-0945. Cancer Discov. 2023. PMID: 37909093 Free PMC article.
Structural insights into Ras regulation by SIN1.
Zheng Y, Ding L, Meng X, Potter M, Kearney AL, Zhang J, Sun J, James DE, Yang G, Zhou C. Zheng Y, et al. Among authors: kearney al. Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2119990119. doi: 10.1073/pnas.2119990119. Epub 2022 May 6. Proc Natl Acad Sci U S A. 2022. PMID: 35522713 Free PMC article.
Global redox proteome and phosphoproteome analysis reveals redox switch in Akt.
Su Z, Burchfield JG, Yang P, Humphrey SJ, Yang G, Francis D, Yasmin S, Shin SY, Norris DM, Kearney AL, Astore MA, Scavuzzo J, Fisher-Wellman KH, Wang QP, Parker BL, Neely GG, Vafaee F, Chiu J, Yeo R, Hogg PJ, Fazakerley DJ, Nguyen LK, Kuyucak S, James DE. Su Z, et al. Among authors: kearney al. Nat Commun. 2019 Dec 2;10(1):5486. doi: 10.1038/s41467-019-13114-4. Nat Commun. 2019. PMID: 31792197 Free PMC article.
Muscle and adipose tissue insulin resistance: malady without mechanism?
Fazakerley DJ, Krycer JR, Kearney AL, Hocking SL, James DE. Fazakerley DJ, et al. Among authors: kearney al. J Lipid Res. 2019 Oct;60(10):1720-1732. doi: 10.1194/jlr.R087510. Epub 2018 Jul 27. J Lipid Res. 2019. PMID: 30054342 Free PMC article. Review.
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