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Macrolide antibiotics allosterically predispose the ribosome for translation arrest.
Sothiselvam S, Liu B, Han W, Ramu H, Klepacki D, Atkinson GC, Brauer A, Remm M, Tenson T, Schulten K, Vázquez-Laslop N, Mankin AS. Sothiselvam S, et al. Among authors: atkinson gc. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9804-9. doi: 10.1073/pnas.1403586111. Epub 2014 Jun 24. Proc Natl Acad Sci U S A. 2014. PMID: 24961372 Free PMC article.
Target protection as a key antibiotic resistance mechanism.
Wilson DN, Hauryliuk V, Atkinson GC, O'Neill AJ. Wilson DN, et al. Among authors: atkinson gc. Nat Rev Microbiol. 2020 Nov;18(11):637-648. doi: 10.1038/s41579-020-0386-z. Epub 2020 Jun 25. Nat Rev Microbiol. 2020. PMID: 32587401 Free article. Review.
Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens.
Crowe-McAuliffe C, Murina V, Turnbull KJ, Kasari M, Mohamad M, Polte C, Takada H, Vaitkevicius K, Johansson J, Ignatova Z, Atkinson GC, O'Neill AJ, Hauryliuk V, Wilson DN. Crowe-McAuliffe C, et al. Among authors: atkinson gc. Nat Commun. 2021 Jun 11;12(1):3577. doi: 10.1038/s41467-021-23753-1. Nat Commun. 2021. PMID: 34117249 Free PMC article.
Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Crowe-McAuliffe C, Murina V, Turnbull KJ, Huch S, Kasari M, Takada H, Nersisyan L, Sundsfjord A, Hegstad K, Atkinson GC, Pelechano V, Wilson DN, Hauryliuk V. Crowe-McAuliffe C, et al. Among authors: atkinson gc. Nat Commun. 2022 Apr 6;13(1):1860. doi: 10.1038/s41467-022-29274-9. Nat Commun. 2022. PMID: 35387982 Free PMC article.
Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint.
Tamman H, Ernits K, Roghanian M, Ainelo A, Julius C, Perrier A, Talavera A, Ainelo H, Dugauquier R, Zedek S, Thureau A, Pérez J, Lima-Mendez G, Hallez R, Atkinson GC, Hauryliuk V, Garcia-Pino A. Tamman H, et al. Among authors: atkinson gc. Nat Chem Biol. 2023 Mar;19(3):334-345. doi: 10.1038/s41589-022-01198-x. Epub 2022 Dec 5. Nat Chem Biol. 2023. PMID: 36470996 Free PMC article.
Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it.
Aleksandrova EV, Wu KJY, Tresco BIC, Syroegin EA, Killeavy EE, Balasanyants SM, Svetlov MS, Gregory ST, Atkinson GC, Myers AG, Polikanov YS. Aleksandrova EV, et al. Among authors: atkinson gc. Nat Chem Biol. 2024 Jul;20(7):867-876. doi: 10.1038/s41589-023-01525-w. Epub 2024 Jan 18. Nat Chem Biol. 2024. PMID: 38238495
Toxic Small Alarmone Synthetase FaRel2 inhibits translation by pyrophosphorylating tRNAGly and tRNAThr.
Kurata T, Takegawa M, Ohira T, Syroegin EA, Atkinson GC, Johansson MJO, Polikanov YS, Garcia-Pino A, Suzuki T, Hauryliuk V. Kurata T, et al. Among authors: atkinson gc. bioRxiv [Preprint]. 2024 Jul 5:2024.07.05.602228. doi: 10.1101/2024.07.05.602228. bioRxiv. 2024. Update in: Sci Adv. 2024 Nov 15;10(46):eadr9624. doi: 10.1126/sciadv.adr9624 PMID: 39005314 Free PMC article. Updated. Preprint.
62 results