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Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.
Sharma R, Reinstadler B, Engelstad K, Skinner OS, Stackowitz E, Haller RG, Clish CB, Pierce K, Walker MA, Fryer R, Oglesbee D, Mao X, Shungu DC, Khatri A, Hirano M, De Vivo DC, Mootha VK. Sharma R, et al. Among authors: reinstadler b. J Clin Invest. 2021 Jan 19;131(2):e136055. doi: 10.1172/JCI136055. J Clin Invest. 2021. PMID: 33463549 Free PMC article. Clinical Trial.
Hypoxia ameliorates brain hyperoxia and NAD+ deficiency in a murine model of Leigh syndrome.
Grange RMH, Sharma R, Shah H, Reinstadler B, Goldberger O, Cooper MK, Nakagawa A, Miyazaki Y, Hindle AG, Batten AJ, Wojtkiewicz GR, Schleifer G, Bagchi A, Marutani E, Malhotra R, Bloch DB, Ichinose F, Mootha VK, Zapol WM. Grange RMH, et al. Among authors: reinstadler b. Mol Genet Metab. 2021 May;133(1):83-93. doi: 10.1016/j.ymgme.2021.03.005. Epub 2021 Mar 11. Mol Genet Metab. 2021. PMID: 33752971 Free PMC article.
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Wang LW, Shen H, Nobre L, Ersing I, Paulo JA, Trudeau S, Wang Z, Smith NA, Ma Y, Reinstadler B, Nomburg J, Sommermann T, Cahir-McFarland E, Gygi SP, Mootha VK, Weekes MP, Gewurz BE. Wang LW, et al. Among authors: reinstadler b. Cell Metab. 2019 Sep 3;30(3):539-555.e11. doi: 10.1016/j.cmet.2019.06.003. Epub 2019 Jun 27. Cell Metab. 2019. PMID: 31257153 Free PMC article.