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Interleukin-37 improves T-cell-mediated immunity and chimeric antigen receptor T-cell therapy in aged backgrounds.
Hamilton JAG, Lee MY, Hunter R, Ank RS, Story JY, Talekar G, Sisroe T, Ballak DB, Fedanov A, Porter CC, Eisenmesser EZ, Dinarello CA, Raikar SS, DeGregori J, Henry CJ. Hamilton JAG, et al. Among authors: dinarello ca. Aging Cell. 2021 Feb;20(2):e13309. doi: 10.1111/acel.13309. Epub 2021 Jan 22. Aging Cell. 2021. PMID: 33480151 Free PMC article.
IL-37 is a fundamental inhibitor of innate immunity.
Nold MF, Nold-Petry CA, Zepp JA, Palmer BE, Bufler P, Dinarello CA. Nold MF, et al. Among authors: dinarello ca. Nat Immunol. 2010 Nov;11(11):1014-22. doi: 10.1038/ni.1944. Epub 2010 Oct 10. Nat Immunol. 2010. PMID: 20935647 Free PMC article.
IL-37 protects against obesity-induced inflammation and insulin resistance.
Ballak DB, van Diepen JA, Moschen AR, Jansen HJ, Hijmans A, Groenhof GJ, Leenders F, Bufler P, Boekschoten MV, Müller M, Kersten S, Li S, Kim S, Eini H, Lewis EC, Joosten LA, Tilg H, Netea MG, Tack CJ, Dinarello CA, Stienstra R. Ballak DB, et al. Among authors: dinarello ca. Nat Commun. 2014 Sep 3;5:4711. doi: 10.1038/ncomms5711. Nat Commun. 2014. PMID: 25182023 Free article.
Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice.
Zeng Q, Song R, Fullerton DA, Ao L, Zhai Y, Li S, Ballak DB, Cleveland JC Jr, Reece TB, McKinsey TA, Xu D, Dinarello CA, Meng X. Zeng Q, et al. Among authors: dinarello ca. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1631-1636. doi: 10.1073/pnas.1619667114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137840 Free PMC article.
Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance.
Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA. Cavalli G, et al. Among authors: dinarello ca. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2313-2318. doi: 10.1073/pnas.1619011114. Epub 2017 Feb 13. Proc Natl Acad Sci U S A. 2017. PMID: 28193888 Free PMC article.
Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects.
Davegårdh C, Broholm C, Perfilyev A, Henriksen T, García-Calzón S, Peijs L, Hansen NS, Volkov P, Kjøbsted R, Wojtaszewski JF, Pedersen M, Pedersen BK, Ballak DB, Dinarello CA, Heinhuis B, Joosten LA, Nilsson E, Vaag A, Scheele C, Ling C. Davegårdh C, et al. Among authors: dinarello ca. BMC Med. 2017 Feb 22;15(1):39. doi: 10.1186/s12916-017-0792-x. BMC Med. 2017. PMID: 28222718 Free PMC article.
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA. Marchetti C, et al. Among authors: dinarello ca. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539. doi: 10.1073/pnas.1716095115. Epub 2018 Jan 29. Proc Natl Acad Sci U S A. 2018. PMID: 29378952 Free PMC article.
1,093 results