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274 results

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Page 1
Katacine Is a New Ligand of CLEC-2 that Acts as a Platelet Agonist.
Morán LA, Di Y, Sowa MA, Hermida-Nogueira L, Barrachina MN, Martin E, Clark JC, Mize TH, Eble JA, Moreira D, Pollitt AY, Loza MI, Domínguez E, Watson SP, García Á. Morán LA, et al. Among authors: clark jc. Thromb Haemost. 2022 Aug;122(8):1361-1368. doi: 10.1055/a-1772-1069. Epub 2022 Feb 15. Thromb Haemost. 2022. PMID: 35170009 Free PMC article.
S100A8/A9 drives the formation of procoagulant platelets through GPIbα.
Colicchia M, Schrottmaier WC, Perrella G, Reyat JS, Begum J, Slater A, Price J, Clark JC, Zhi Z, Simpson MJ, Bourne JH, Poulter NS, Khan AO, Nicolson PLR, Pugh M, Harrison P, Iqbal AJ, Rainger GE, Watson SP, Thomas MR, Mutch NJ, Assinger A, Rayes J. Colicchia M, et al. Among authors: clark jc. Blood. 2022 Dec 15;140(24):2626-2643. doi: 10.1182/blood.2021014966. Blood. 2022. PMID: 36026606 Free PMC article.
Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition.
Billiald P, Slater A, Welin M, Clark JC, Loyau S, Pugnière M, Jiacomini IG, Rose N, Lebozec K, Toledano E, François D, Watson SP, Jandrot-Perrus M. Billiald P, et al. Among authors: clark jc. Blood Adv. 2023 Apr 11;7(7):1258-1268. doi: 10.1182/bloodadvances.2022007863. Blood Adv. 2023. PMID: 36375047 Free PMC article.
Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins.
Maqsood Z, Clark JC, Martin EM, Cheung YFH, Morán LA, Watson SET, Pike JA, Di Y, Poulter NS, Slater A, Lange BMH, Nieswandt B, Eble JA, Tomlinson MG, Owen DM, Stegner D, Bridge LJ, Wierling C, Watson SP. Maqsood Z, et al. Among authors: clark jc. PLoS Comput Biol. 2022 Nov 28;18(11):e1010708. doi: 10.1371/journal.pcbi.1010708. eCollection 2022 Nov. PLoS Comput Biol. 2022. PMID: 36441766 Free PMC article.
Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization.
Damaskinaki FN, Jooss NJ, Martin EM, Clark JC, Thomas MR, Poulter NS, Emsley J, Kellam B, Watson SP, Slater A. Damaskinaki FN, et al. Among authors: clark jc. J Thromb Haemost. 2023 Feb;21(2):317-328. doi: 10.1016/j.jtha.2022.11.002. Epub 2022 Dec 22. J Thromb Haemost. 2023. PMID: 36700508 Free article.
Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists.
Clark JC, Martin EM, Morán LA, Di Y, Wang X, Zuidscherwoude M, Brown HC, Kavanagh DM, Hummert J, Eble JA, Nieswandt B, Stegner D, Pollitt AY, Herten DP, Tomlinson MG, García A, Watson SP. Clark JC, et al. Commun Biol. 2023 Apr 7;6(1):376. doi: 10.1038/s42003-023-04766-6. Commun Biol. 2023. PMID: 37029319 Free PMC article.
274 results