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A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs.
McCarthy JS, Sekuloski S, Griffin PM, Elliott S, Douglas N, Peatey C, Rockett R, O'Rourke P, Marquart L, Hermsen C, Duparc S, Möhrle J, Trenholme KR, Humberstone AJ. McCarthy JS, et al. PLoS One. 2011;6(8):e21914. doi: 10.1371/journal.pone.0021914. Epub 2011 Aug 22. PLoS One. 2011. PMID: 21887214 Free PMC article. Clinical Trial.
Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivax.
Marfurt J, Chalfein F, Prayoga P, Wabiser F, Wirjanata G, Sebayang B, Piera KA, Wittlin S, Haynes RK, Möhrle JJ, Anstey NM, Kenangalem E, Price RN. Marfurt J, et al. Among authors: mohrle jj. Antimicrob Agents Chemother. 2012 Oct;56(10):5258-63. doi: 10.1128/AAC.00283-12. Epub 2012 Jul 30. Antimicrob Agents Chemother. 2012. PMID: 22850522 Free PMC article.
Repositioning: the fast track to new anti-malarial medicines?
Lotharius J, Gamo-Benito FJ, Angulo-Barturen I, Clark J, Connelly M, Ferrer-Bazaga S, Parkinson T, Viswanath P, Bandodkar B, Rautela N, Bharath S, Duffy S, Avery VM, Möhrle JJ, Guy RK, Wells T. Lotharius J, et al. Among authors: mohrle jj. Malar J. 2014 Apr 14;13:143. doi: 10.1186/1475-2875-13-143. Malar J. 2014. PMID: 24731288 Free PMC article.
Potent Ex Vivo Activity of Naphthoquine and Methylene Blue against Drug-Resistant Clinical Isolates of Plasmodium falciparum and Plasmodium vivax.
Wirjanata G, Sebayang BF, Chalfein F, Prayoga, Handayuni I, Trianty L, Kenangalem E, Noviyanti R, Campo B, Poespoprodjo JR, Möhrle JJ, Price RN, Marfurt J. Wirjanata G, et al. Among authors: mohrle jj. Antimicrob Agents Chemother. 2015 Oct;59(10):6117-24. doi: 10.1128/AAC.00874-15. Epub 2015 Jul 20. Antimicrob Agents Chemother. 2015. PMID: 26195523 Free PMC article.
Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial.
Phyo AP, Jittamala P, Nosten FH, Pukrittayakamee S, Imwong M, White NJ, Duparc S, Macintyre F, Baker M, Möhrle JJ. Phyo AP, et al. Among authors: mohrle jj. Lancet Infect Dis. 2016 Jan;16(1):61-69. doi: 10.1016/S1473-3099(15)00320-5. Epub 2015 Oct 5. Lancet Infect Dis. 2016. PMID: 26448141 Free PMC article. Clinical Trial.
Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development.
McCarthy JS, Marquart L, Sekuloski S, Trenholme K, Elliott S, Griffin P, Rockett R, O'Rourke P, Sloots T, Angulo-Barturen I, Ferrer S, Jiménez-Díaz MB, Martínez MS, Hooft van Huijsduijnen R, Duparc S, Leroy D, Wells TN, Baker M, Möhrle JJ. McCarthy JS, et al. Among authors: mohrle jj. Antimicrob Agents Chemother. 2016 May 23;60(6):3669-75. doi: 10.1128/AAC.02883-15. Print 2016 Jun. Antimicrob Agents Chemother. 2016. PMID: 27044554 Free PMC article. Clinical Trial.
Piperaquine Monotherapy of Drug-Susceptible Plasmodium falciparum Infection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia.
Pasay CJ, Rockett R, Sekuloski S, Griffin P, Marquart L, Peatey C, Wang CY, O'Rourke P, Elliott S, Baker M, Möhrle JJ, McCarthy JS. Pasay CJ, et al. Among authors: mohrle jj. J Infect Dis. 2016 Jul 1;214(1):105-13. doi: 10.1093/infdis/jiw128. Epub 2016 Apr 7. J Infect Dis. 2016. PMID: 27056954 Free PMC article. Clinical Trial.
63 results