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IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions.
Mucciolo G, Curcio C, Roux C, Li WY, Capello M, Curto R, Chiarle R, Giordano D, Satolli MA, Lawlor R, Scarpa A, Lukac P, Stakheev D, Provero P, Vannucci L, Mak TW, Novelli F, Cappello P. Mucciolo G, et al. Among authors: li wy. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2020395118. doi: 10.1073/pnas.2020395118. Proc Natl Acad Sci U S A. 2021. PMID: 33526692 Free PMC article.
The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.
Hao Z, Duncan GS, Su YW, Li WY, Silvester J, Hong C, You H, Brenner D, Gorrini C, Haight J, Wakeham A, You-Ten A, McCracken S, Elia A, Li Q, Detmar J, Jurisicova A, Hobeika E, Reth M, Sheng Y, Lang PA, Ohashi PS, Zhong Q, Wang X, Mak TW. Hao Z, et al. Among authors: li wy, li q. J Exp Med. 2012 Jan 16;209(1):173-86. doi: 10.1084/jem.20111363. Epub 2012 Jan 2. J Exp Med. 2012. PMID: 22213803 Free PMC article.
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.
Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW. Inoue S, et al. Among authors: li wy. Genes Dev. 2013 May 15;27(10):1101-14. doi: 10.1101/gad.214577.113. Genes Dev. 2013. PMID: 23699408 Free PMC article.
TAp73 is required for spermatogenesis and the maintenance of male fertility.
Inoue S, Tomasini R, Rufini A, Elia AJ, Agostini M, Amelio I, Cescon D, Dinsdale D, Zhou L, Harris IS, Lac S, Silvester J, Li WY, Sasaki M, Haight J, Brüstle A, Wakeham A, McKerlie C, Jurisicova A, Melino G, Mak TW. Inoue S, et al. Among authors: li wy. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1843-8. doi: 10.1073/pnas.1323416111. Epub 2014 Jan 21. Proc Natl Acad Sci U S A. 2014. PMID: 24449892 Free PMC article.
Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway.
Gorrini C, Gang BP, Bassi C, Wakeham A, Baniasadi SP, Hao Z, Li WY, Cescon DW, Li YT, Molyneux S, Penrod N, Lupien M, Schmidt EE, Stambolic V, Gauthier ML, Mak TW. Gorrini C, et al. Among authors: li wy, li yt. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4472-7. doi: 10.1073/pnas.1324136111. Epub 2014 Feb 24. Proc Natl Acad Sci U S A. 2014. PMID: 24567396 Free PMC article.
Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis.
Afzal S, Hao Z, Itsumi M, Abouelkheer Y, Brenner D, Gao Y, Wakeham A, Hong C, Li WY, Sylvester J, Gilani SO, Brüstle A, Haight J, You-Ten AJ, Lin GH, Inoue S, Mak TW. Afzal S, et al. Among authors: li wy. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1119-24. doi: 10.1073/pnas.1423588112. Epub 2015 Jan 12. Proc Natl Acad Sci U S A. 2015. PMID: 25583492 Free PMC article.
Mutant IDH is sufficient to initiate enchondromatosis in mice.
Hirata M, Sasaki M, Cairns RA, Inoue S, Puviindran V, Li WY, Snow BE, Jones LD, Wei Q, Sato S, Tang YJ, Nadesan P, Rockel J, Whetstone H, Poon R, Weng A, Gross S, Straley K, Gliser C, Xu Y, Wunder J, Mak TW, Alman BA. Hirata M, et al. Among authors: li wy. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2829-34. doi: 10.1073/pnas.1424400112. Epub 2015 Feb 17. Proc Natl Acad Sci U S A. 2015. PMID: 25730874 Free PMC article.
Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.
Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW. Itsumi M, et al. Among authors: li wy. Cell Death Differ. 2015 Nov;22(11):1837-45. doi: 10.1038/cdd.2015.38. Epub 2015 Apr 17. Cell Death Differ. 2015. PMID: 25882048 Free PMC article.
1,194 results