Maddukuri L - Search Results

1

Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs.

Ketkar A, Smith L, Johnson C, Richey A, Berry M, Hartman JH, Maddukuri L, Reed MR, Gunderson JEC, Leung JWC, Eoff RL. Ketkar A, et al. Among authors: maddukuri l. Nucleic Acids Res. 2021 Feb 26;49(4):2065-2084. doi: 10.1093/nar/gkab041. Nucleic Acids Res. 2021. PMID: 33555350 Free PMC article.

2

Human Rev1 polymerase disrupts G-quadruplex DNA.

Eddy S, Ketkar A, Zafar MK, Maddukuri L, Choi JY, Eoff RL. Eddy S, et al. Among authors: maddukuri l. Nucleic Acids Res. 2014 Mar;42(5):3272-85. doi: 10.1093/nar/gkt1314. Epub 2013 Dec 23. Nucleic Acids Res. 2014. PMID: 24366879 Free PMC article.

3

The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa.

Maddukuri L, Ketkar A, Eddy S, Zafar MK, Eoff RL. Maddukuri L, et al. Nucleic Acids Res. 2014 Oct 29;42(19):12027-40. doi: 10.1093/nar/gku913. Epub 2014 Oct 7. Nucleic Acids Res. 2014. PMID: 25294835 Free PMC article.

4

Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA.

Eddy S, Tillman M, Maddukuri L, Ketkar A, Zafar MK, Eoff RL. Eddy S, et al. Among authors: maddukuri l. Biochemistry. 2016 Sep 20;55(37):5218-29. doi: 10.1021/acs.biochem.6b00374. Epub 2016 Sep 7. Biochemistry. 2016. PMID: 27525498 Free PMC article.

5

Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein.

Maddukuri L, Ketkar A, Eddy S, Zafar MK, Griffin WC, Eoff RL. Maddukuri L, et al. J Biol Chem. 2012 Dec 7;287(50):42312-23. doi: 10.1074/jbc.M112.410332. Epub 2012 Oct 8. J Biol Chem. 2012. PMID: 23045531 Free PMC article.

6

Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity.

Ketkar A, Zafar MK, Maddukuri L, Yamanaka K, Banerjee S, Egli M, Choi JY, Lloyd RS, Eoff RL. Ketkar A, et al. Among authors: maddukuri l. Chem Res Toxicol. 2013 Feb 18;26(2):221-32. doi: 10.1021/tx300392m. Epub 2013 Jan 31. Chem Res Toxicol. 2013. PMID: 23305233 Free PMC article.

7

Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA.

Eddy S, Maddukuri L, Ketkar A, Zafar MK, Henninger EE, Pursell ZF, Eoff RL. Eddy S, et al. Among authors: maddukuri l. Biochemistry. 2015 May 26;54(20):3218-30. doi: 10.1021/acs.biochem.5b00060. Epub 2015 May 11. Biochemistry. 2015. PMID: 25903680 Free PMC article.

8

Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.

Bostian AC, Maddukuri L, Reed MR, Savenka T, Hartman JH, Davis L, Pouncey DL, Miller GP, Eoff RL. Bostian AC, et al. Among authors: maddukuri l. Chem Res Toxicol. 2016 Jan 19;29(1):101-8. doi: 10.1021/acs.chemrestox.5b00452. Epub 2015 Dec 30. Chem Res Toxicol. 2016. PMID: 26651356 Free PMC article.

9

A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells.

Zafar MK, Maddukuri L, Ketkar A, Penthala NR, Reed MR, Eddy S, Crooks PA, Eoff RL. Zafar MK, et al. Among authors: maddukuri l. Biochemistry. 2018 Feb 20;57(7):1262-1273. doi: 10.1021/acs.biochem.7b01176. Epub 2018 Jan 30. Biochemistry. 2018. PMID: 29345908 Free PMC article.

10

Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms.

Ketkar A, Maddukuri L, Penthala NR, Reed MR, Zafar MK, Crooks PA, Eoff RL. Ketkar A, et al. Among authors: maddukuri l. ACS Chem Biol. 2019 Jun 21;14(6):1337-1351. doi: 10.1021/acschembio.9b00304. Epub 2019 May 22. ACS Chem Biol. 2019. PMID: 31082191 Free PMC article.

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