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Site-specific O-glycosylation analysis of SARS-CoV-2 spike protein produced in insect and human cells.
Bagdonaite I, Thompson AJ, Wang X, Søgaard M, Fougeroux C, Frank M, Diedrich JK, Yates JR, Salanti A, Vakhrushev SY, Paulson JC, Wandall HH. Bagdonaite I, et al. Among authors: vakhrushev sy. bioRxiv [Preprint]. 2021 Feb 10:2021.02.03.429627. doi: 10.1101/2021.02.03.429627. bioRxiv. 2021. Update in: Viruses. 2021 Mar 25;13(4):551. doi: 10.3390/v13040551 PMID: 33564762 Free PMC article. Updated. Preprint.
The SHDRA syndrome-associated gene TMEM260 encodes a protein-specific O-mannosyltransferase.
Larsen ISB, Povolo L, Zhou L, Tian W, Mygind KJ, Hintze J, Jiang C, Hartill V, Prescott K, Johnson CA, Mullegama SV, McConkie-Rosell A, McDonald M, Hansen L, Vakhrushev SY, Schjoldager KT, Clausen H, Worzfeld T, Joshi HJ, Halim A. Larsen ISB, et al. Among authors: vakhrushev sy. Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2302584120. doi: 10.1073/pnas.2302584120. Epub 2023 May 15. Proc Natl Acad Sci U S A. 2023. PMID: 37186866 Free PMC article.
Fish-hunting cone snail disrupts prey's glucose homeostasis with weaponized mimetics of somatostatin and insulin.
Yeung HY, Ramiro IBL, Andersen DB, Koch TL, Hamilton A, Bjørn-Yoshimoto WE, Espino S, Vakhrushev SY, Pedersen KB, de Haan N, Hipgrave Ederveen AL, Olivera BM, Knudsen JG, Bräuner-Osborne H, Schjoldager KT, Holst JJ, Safavi-Hemami H. Yeung HY, et al. Among authors: vakhrushev sy. Nat Commun. 2024 Aug 20;15(1):6408. doi: 10.1038/s41467-024-50470-2. Nat Commun. 2024. PMID: 39164229 Free PMC article.
Development of a FUT8 Inhibitor with Cellular Inhibitory Properties.
Manabe Y, Takebe T, Kasahara S, Hizume K, Kabayama K, Kamada Y, Asakura A, Shinzaki S, Takamatsu S, Miyoshi E, García-García A, Vakhrushev SY, Hurtado-Guerrero R, Fukase K. Manabe Y, et al. Among authors: vakhrushev sy. Angew Chem Int Ed Engl. 2024 Sep 28:e202414682. doi: 10.1002/anie.202414682. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 39340265
A universal GlycoDesign for lysosomal replacement enzymes to improve circulation time and biodistribution.
Chen YH, Tian W, Yasuda M, Ye Z, Song M, Mandel U, Kristensen C, Povolo L, Marques ARA, Čaval T, Heck AJR, Sampaio JL, Johannes L, Tsukimura T, Desnick R, Vakhrushev SY, Yang Z, Clausen H. Chen YH, et al. Among authors: vakhrushev sy. Front Bioeng Biotechnol. 2023 Feb 24;11:1128371. doi: 10.3389/fbioe.2023.1128371. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 36911201 Free PMC article.
De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium.
Lavrsen K, Dabelsteen S, Vakhrushev SY, Levann AMR, Haue AD, Dylander A, Mandel U, Hansen L, Frödin M, Bennett EP, Wandall HH. Lavrsen K, et al. Among authors: vakhrushev sy. J Biol Chem. 2018 Jan 26;293(4):1298-1314. doi: 10.1074/jbc.M117.812826. Epub 2017 Nov 29. J Biol Chem. 2018. PMID: 29187600 Free PMC article.
97 results